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Zimberelimab Biosimilar - Research Grade

Name: Zimberelimab Biosimilar - Research Grade
SKU: ICH5292
Price: 2654 USD
Availability: InStock

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SKU

ICH5292

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$710.00 - $19,500.00

Zimberelimab Biosimilar - Research Grade

Endotoxin

≤ 1.0 EU/mg as determined by the LAL method

Purity

>95% by SDS-PAGE

Species Reactivity

Human

Target

PD-1

Concentration

>1mg/ml

Isotype

Human IgG4 - lambda

Host

CHO Cells

Antibodies Against The Same Target

Sequence

https://www.imgt.org/mAb-DB/

Buffer

ICH3002

Uniprot

Q15116

Shipping Conditions

Blue ice

Background

This product is a research-grade biosimilar of zimberelimab, an anti-PD-1 antibody. It is supplied as an unconjugated, non-therapeutic analog of the originator molecule and is intended strictly for research use only; it is not a clinical drug and is not for human or veterinary use. The antibody is built around the programmed cell death protein 1 (PD-1) target and is expressed as a human IgG4 (lambda) format, mirroring the isotype of the reference molecule. As with other IgG4-based checkpoint biosimilars, it recapitulates the antigen-binding properties of the originator while carrying the stabilized, low-effector-function characteristics associated with the IgG4 subclass. It is manufactured to research-grade endotoxin specifications (typically less than 1 EU/mg), and is available in bulk milligram-to-gram quantities suitable for in-vitro assays, screening cascades, and use as a reference or comparator reagent. It provides a cost-effective, consistently sourced alternative to therapeutic material for investigators studying PD-1 biology, checkpoint blockade mechanisms, and assay development, where a well-characterized anti-PD-1 binder is required. PD-1 (programmed cell death protein 1, gene PDCD1) is an inhibitory immune checkpoint receptor expressed on activated T cells, B cells, and myeloid cells. It is a type I transmembrane protein of the immunoglobulin superfamily bearing intracellular ITIM and ITSM motifs. Engagement by its ligands PD-L1 and PD-L2 recruits the phosphatase SHP-2, which dampens TCR and CD28 signaling, attenuating T-cell activation, proliferation, and cytokine production. This pathway maintains peripheral tolerance and limits immunopathology, but tumors and chronic infections exploit it to drive T-cell exhaustion and immune evasion. Antibodies that block the PD-1/PD-L1 axis restore effector T-cell function and underpin a major class of cancer immunotherapies. PD-1 is therefore a central node in studies of tumor immunology, checkpoint blockade, and T-cell dysfunction.

Other Names

Protein PD-1, hPD-1, Programmed cell death protein 1, PDCD1

Specificity

Detects human PD-1

Purification Method

This monoclonal antibody was purified using Protein A

Formulation

Sterile, preservative-free, solution in PBS. BSA and Azide free.

Storage

This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.

Applications

Functional Assays