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Balstilimab Biosimilar - Research Grade

Name: Balstilimab Biosimilar - Research Grade
SKU: ICH5369-10mg
Price: 2654 USD
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ICH5369-10mg

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Balstilimab Biosimilar - Research Grade

Endotoxin

≤ 1.0 EU/mg as determined by the LAL method

Purity

>90% by SDS-PAGE

Species Reactivity

Human

Target

PDCD1

Concentration

>1mg/ml

Isotype

IgG4 - kappa

Host

CHO Cells

Antibodies Against The Same Target

Sequence

https://www.imgt.org/mAb-DB/

Buffer

ICH3002

Uniprot

Q15116

Shipping Conditions

Blue ice

Background

This product is a research-grade biosimilar of balstilimab, supplied as an unconjugated, non-therapeutic analog of the originator anti-PD-1 antibody for research use only. It is built around the programmed cell death protein 1 (PD-1, PDCD1) target and carries a human IgG4-kappa framework matching the originator's format. It is intended as a functional research tool for in-vitro binding, receptor-blockade, and reporter or cell-based assays, and as a reference or control reagent in checkpoint-inhibitor studies, not for any clinical or diagnostic application. Manufactured to low-endotoxin standards (research grade typically under 1 EU/mg) and available in bulk milligram-to-gram quantities, it supports reproducible, well-controlled experimental work. Because it reproduces the antigen-binding properties of the originator without any conjugate or label, it is well suited to comparative studies, assay development, and neutralization or competition experiments. Note that this analog targets human PD-1, so it is generally not appropriate for routine mouse in-vivo checkpoint-blockade dosing; investigators working in murine models should use an anti-mouse PD-1 clone instead. All characterization data should be confirmed in the user's own system. PD-1 (PDCD1, UniProt Q15116) is an inhibitory immune checkpoint receptor expressed on activated T cells, B cells, NK cells, and other immune subsets. Engagement of PD-1 by its ligands PD-L1 (CD274) and PD-L2 (PDCD1LG2) recruits phosphatases such as SHP-2 to the receptor's ITIM and ITSM motifs, dampening TCR and CD28 signaling and attenuating T-cell proliferation, cytokine production, and cytotoxic activity. This pathway maintains peripheral tolerance and limits immunopathology, but tumors and chronically infected tissues co-opt it to drive T-cell exhaustion and immune escape. Antibodies that block the PD-1/PD-L1 axis can restore effector T-cell function, which underlies the therapeutic rationale for anti-PD-1 checkpoint inhibitors and makes PD-1 a central target in tumor immunology and immunotherapy research.

Other Names

Protein PD-1, hPD-1, Programmed cell death protein 1, PD1

Purification Method

This monoclonal antibody was purified using Protein A

Formulation

Sterile, preservative-free, solution in PBS. BSA and Azide free.

Storage

This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.

Applications

Functional Assays

Application Notes

This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.