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Atibuclimab Biosimilar - Research Grade
Atibuclimab Biosimilar - Research Grade
Product Details:ichorbio's atibuclimab biosimilar is for Research Use Only (RUO)
Size:ichorbio's RUO atibuclimab biosimilar is available in the following sizes: 1mg, 5mg, 10mg, 20mg, 50mg, 100mg ichorbio regularly manufactures bulk multi-gram amounts of this biosimilar - please contact us for pricing.
Target:CD14
Isotype:IgG4
Other Names:IC14
Host:CHO cells
Species Reactivity:Human
Specificity:Detects human CD14.
Purification Method:This recombinant protein was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background:RUO atibuclimab is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis. It acts as a pattern recognition receptor for bacterial cell wall components in gram-positive and negative bacteria. CD14 antibody action stimulates a pro-inflammatory cytokine cascade often associated with inflammation in sepsis. Atibuclimab neutralization of this antibody results in the inhibition of TNF-a, IL-6 and IL-10, dampening systemic inflammatory responses. Atibuclimab also delays the release of sTNFR(1) and IL-1ra.
Concentration:1.0 - 5.0 mg/ml
Formulation:Sterile, preservative-free, solution in PBS. BSA and Azide free.
Purity:>95% by SDS-PAGE and HPLC
Endotoxin:≤ 1.0 EU/mg as determined by the LAL method
Storage:Atibuclimab Biosimilar - Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Applications:Functional Assays
Application Notes:Each investigator should determine their own optimal working dilution for specific applications.
Isotype Control: Use: ichorbio's atibuclimab biosimilar is for research use only (RUO).| Concentration | 5.12mg/ml |
|---|---|
| isotype | IgG4 |
| Host | CHO cells |
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