Gilvetmab Biosimilar - Research Grade

Name: Gilvetmab Biosimilar - Research Grade
SKU: ICH5572-10mg
Price: 2654 USD
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SKU

ICH5572-10mg

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Gilvetmab Biosimilar - Research Grade

Endotoxin

≤ 1.0 EU/mg as determined by the LAL method

Purity

>90% by SDS-PAGE

Species Reactivity

Human

Target

PDCD1

Concentration

>1mg/ml

Isotype

IgG2 - kappa

Host

CHO Cells

Antibodies Against The Same Target

Sequence

https://www.imgt.org/mAb-DB/

Buffer

ICH3002

Uniprot

Q15116

Shipping Conditions

Blue ice

Background

This product is an unconjugated, non-therapeutic recombinant analog of gilvetmab, an anti-PD-1 (PDCD1) monoclonal antibody, supplied for research use only. It is built around the PD-1 target as a research-grade tool and is not the clinical or veterinary drug; it is not intended for human or animal treatment. As a functional analog it is useful as a positive control and reference reagent in PD-1 binding, blockade, and checkpoint-modulation assays, for characterizing PD-1/PD-L1 pathway biology, for benchmarking other anti-PD-1 reagents, and as a building block in ADCC or antibody-engineering and ADC-development workflows. The antibody is offered unconjugated so users can apply their own labels or secondary detection. Formats are typically low-endotoxin (research grade <1 EU/mg; ultra-low <0.5 EU/mg) and available in bulk milligram-to-gram quantities to support in-vitro assays and preclinical model work. Because it is a research reagent rather than a therapeutic, lot-appropriate validation for the intended application is recommended. The card lists human PDCD1 (UniProt Q15116); see the flag note regarding originator species. PD-1 (programmed cell death protein 1), encoded by PDCD1, is a type I transmembrane immunoinhibitory receptor of the CD28/immunoglobulin superfamily. It is expressed on activated T cells, B cells, natural killer cells, and other immune subsets, and is markedly upregulated on chronically stimulated or exhausted T cells. Its cytoplasmic tail carries ITIM and ITSM motifs that, upon ligand engagement, recruit the phosphatase SHP-2 to dampen TCR and CD28 signaling. PD-1 binds two ligands, PD-L1 (CD274) and PD-L2 (PDCD1LG2), which are expressed on antigen-presenting cells and, aberrantly, on many tumors. Ligation delivers a coinhibitory signal that reduces T-cell proliferation, cytokine production, and cytotoxicity, contributing to peripheral tolerance and to tumor immune evasion. Blocking the PD-1/PD-L1 axis restores effector T-cell function, the mechanistic basis of checkpoint-inhibitor immunotherapy.

Other Names

Protein PD-1, hPD-1, Programmed cell death protein 1, PD1

Purification Method

This monoclonal antibody was purified using Protein A

Formulation

Sterile, preservative-free, solution in PBS. BSA and Azide free.

Storage

This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.

Applications

Functional Assays

Application Notes

This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.