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Pimivalimab Biosimilar - Research Grade

Name: Pimivalimab Biosimilar - Research Grade
SKU: ICH5266
Price: 1195 USD
Availability: InStock

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ICH5266

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$710.00 - $19,890.00

Pimivalimab Biosimilar - Research Grade

Endotoxin

≤ 1.0 EU/mg as determined by the LAL method

Purity

>95% by SDS-PAGE

Species Reactivity

Human

Target

PD-1

Concentration

>1mg/ml

Isotype

Human IgG4 - kappa

Host

CHO Cells

Antibodies Against The Same Target

Sequence

https://www.imgt.org/mAb-DB/

Buffer

ICH3002

Uniprot

Q15116

Shipping Conditions

Blue ice

Background

This is a research-grade biosimilar of pimivalimab (JTX-4014), an anti-PD-1 antibody. It is an unconjugated, non-therapeutic recombinant analog built around the PD-1 target, produced as a fully human IgG4-kappa immunoglobulin. It is intended strictly for research use only (RUO) and is not the clinical drug; it is not for human or veterinary use. Because it reproduces the antigen-binding behavior of the originator against human PD-1, it is useful as a defined, reproducible reagent for in-vitro and preclinical work: as a positive control or benchmarking standard alongside other checkpoint blockers, in receptor-ligand binding and blockade assays, in reporter and functional T-cell assays, and as a starting antibody for ADCC/ADC or bispecific development workflows. The material is offered at low-endotoxin research grade (typically less than 1 EU/mg, with ultra-low options under 0.5 EU/mg) and available in bulk milligram-to-gram quantities, supporting assay standardization, in-vitro model systems, and larger preclinical studies where lot-to-lot consistency and cost per milligram matter. PD-1 (programmed cell death protein 1; gene PDCD1, UniProt Q15116) is a type I transmembrane co-inhibitory receptor of the CD28/CTLA-4 immunoglobulin superfamily, expressed on activated T cells and also on B cells, NK cells, and some myeloid cells. It engages two ligands, PD-L1 (CD274) and PD-L2 (CD273). Ligand binding clusters PD-1 with the T-cell receptor and recruits the phosphatase SHP-2 via phosphorylated ITIM and ITSM motifs in the cytoplasmic tail, dampening TCR and CD28 signaling. This delivers an inhibitory checkpoint signal that limits T-cell proliferation, cytokine production, and effector function, maintaining peripheral tolerance and restraining immunopathology. Tumors and chronically infected tissues exploit this axis to drive T-cell exhaustion; blocking PD-1/PD-L1 engagement restores effector responses, the basis of checkpoint-inhibitor immunotherapy.

Other Names

Protein PD-1, hPD-1, Programmed cell death protein 1, PDCD1

Specificity

Detects human PD-1

Purification Method

This monoclonal antibody was purified using Protein A

Formulation

Sterile, preservative-free, solution in PBS. BSA and Azide free.

Storage

This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.

Applications

Functional Assays