Nivolumab Biosimilar - Research Grade

Bulk Nivolumab Biosimilar - Research Grade

Product Benefits:

ichorbio's Nivolumab Biosimilar - Research Grade is manufactured in a cGMP compliant facility. Click here to view ichorbio’s complete list of anti-PD-1 antibodies and biosimilars.

Size:

ichorbio's research grade nivolumab biosimilar is available in the following sizes: 5mg, 10mg, 20mg, 50mg, 100mg ichorbio regularly manufactures bulk multi-gram amounts of our nivolumab biosimilar - please contact us for pricing.

Target:

PD-1

Clone:

n/a

Isotype:

IgG4 (S228P) kappa

Other Names:

Programmed cell death protein 1, Pdcd1, CD279

Host:

Humanized

Species Reactivity:

Human

Specificity:

Detects human PD-1.

Purification Method:

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background:

Nivolumab biosimilar is a human monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2. Nivolumab is an IgG4 kappa immunoglobulin that has a calculated molecular mass of 146 kDa. It is expressed in a recombinant Chinese Hamster Ovary (CHO) cell line.

Concentration:

1.0 - 5.0 mg/ml

Formulation:

Sterile, preservative-free, pyrogen-free, clear to milky white, colorless to pale yellow liquid, containing mannitol, gadopentetate, polysorbate 80, sodium chloride and sodium citrate dihydrate, pH value 6.0. BSA and Azide free.

Purity:

>95% by SDS-PAGE and HPLC

Endotoxin:

≤ 0.75 EU/mg as determined by the LAL method

Storage:

This antibody is stable for at least 4 weeks when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at – 20°C or -80°C. Avoid repeated freeze thaw cycles.

Applications:

Functional Assays

Application Notes:

Each investigator should determine their own optimal working dilution for specific applications.

Isotype Control: Bulk Human IgG4 Isotype Control S228P (IB4) [ICH2257S228P] Use: ichorbio's nivolumab biosimilar is for research use only (RUO). Isotype Control:

Bulk Human IgG4 Isotype Control (IB4) [ICH2257]