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Cemiplimab Biosimilar - Research Grade

Name: Cemiplimab Biosimilar - Research Grade
SKU: ICH5161
Price: 315 USD
Availability: InStock

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ICH5161

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$315.00 - $19,890.00

Cemiplimab Biosimilar - Research Grade

Endotoxin

<1EU/mg Determined by LAL gel clotting assay

Purity

≥95% monomer by analytical SEC, >95% by SDS Page

Species Reactivity

Human

Target

PD-1

Concentration

>1mg/ml

Isotype

Human IgG4 S228P Kappa

Antibodies Against The Same Target

Sequence

https://www.imgt.org/mAb-DB/

Buffer

ICH3002

Uniprot

Q15116

Shipping Conditions

Blue ice

Background

This is a research-grade, unconjugated recombinant analog of cemiplimab, an anti-PD-1 antibody, supplied strictly for research use only and not as the clinical therapeutic. It is built as a human IgG4 (S228P-stabilized) kappa antibody directed against human PD-1 (PDCD1, UniProt Q15116), reproducing the target specificity of the originator so investigators can probe PD-1 biology and checkpoint signaling in controlled settings. Typical applications include binding and blocking assays, use as a positive control or reference antibody in immune-checkpoint studies, benchmarking of biosimilar or novel anti-PD-1 candidates, and as a tool reagent in ADCC/engineering and antibody-development workflows. It is offered at low endotoxin levels (research grade <1 EU/mg; ultra-low <0.5 EU/mg) and available in bulk milligram-to-gram quantities to support in-vitro assays, preclinical model work, and scale-dependent screening. Because it is a non-therapeutic analog, it is intended only for laboratory investigation and is not for human or veterinary use. It lets labs study PD-1 blockade without sourcing clinical drug product. PD-1 (programmed cell death protein 1; gene PDCD1, UniProt Q15116) is an inhibitory immune checkpoint receptor of the CD28/B7 family expressed on activated T cells, B cells, NK cells, and other immune subsets. It carries an immunoreceptor tyrosine-based inhibitory motif (ITIM) and switch motif (ITSM) in its cytoplasmic tail; engagement by its ligands PD-L1 (CD274) and PD-L2 (PDCD1LG2) recruits the phosphatase SHP-2, dampening TCR and CD28 signaling to attenuate T-cell activation, proliferation, and cytokine production. This pathway maintains peripheral tolerance and limits immunopathology, but tumors and chronic infections co-opt it to drive T-cell exhaustion and immune escape. Antibodies that block the PD-1/PD-L1 axis restore effector T-cell function, the basis of checkpoint-inhibitor immunotherapy.

Other Names

Protein PD-1, hPD-1, Programmed cell death protein 1, PDCD1

Specificity

Detects human PD-1

Purification Method

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Fc Modification

S228P

Formulation

Sterile, preservative-free, solution in PBS. BSA and Azide free.

Storage

This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.