Bulk Anti-Human CD2 (G11) Antibody

Human

CD2

>1mg/ml

Mouse IgG2a

Mouse

Bulk Anti-Human CD2 (LO-CD2a) In Vivo Antibody (ICH1193), Siplizumab Biosimilar - Research Grade (ICH5867)

Aggregation level ≤ 5%

The CD2 antigen is present on approximately 80% of normal peripheral blood lymphocytes, >95% of thymocytes, 100% of mature circulating T-cells and a subset of NK cells.

ICH3001-100ml ICH3002-100ml ICH3003-100ml

P06729

Blue ice

This is clone G11, a mouse monoclonal antibody of the IgG2a isotype (mouse host) directed against human CD2 (UniProt P06729). It is offered as a bulk, research-use-only reagent manufactured to low-endotoxin standards, making it well suited to functional immunology and cell-signalling studies where large or repeated antibody quantities are required. As a well-characterised anti-human CD2 clone, it is validated for Western blot and functional assays, and its bulk format supports scale-up work such as T-cell and NK-cell activation or blocking experiments, ex vivo stimulation panels, and assay development where consistent lot performance across many samples matters. The mouse IgG2a backbone is a common, well-understood isotype for in-vitro functional work. Because CD2 is a human target, this antibody is intended for human-cell and human-tissue studies rather than mouse in-vivo models. Its combination of defined clonality, low endotoxin, and bulk availability makes it a practical choice for laboratories standardising CD2-focused functional readouts at scale. CD2 (UniProt P06729), also called LFA-2 or the T11/E-rosette receptor, is a cell-surface adhesion and costimulatory glycoprotein of the immunoglobulin superfamily expressed on T cells and natural killer cells. Its principal ligand in humans is CD58 (LFA-3), and engagement of the CD2-CD58 axis strengthens the adhesion between T cells and antigen-presenting or target cells, helping to stabilise the immunological synapse. Beyond adhesion, CD2 delivers costimulatory signals that lower the threshold for T-cell receptor activation and contribute to T-cell proliferation, cytokine production, and NK-cell cytotoxicity. The cytoplasmic tail couples to intracellular signalling and cytoskeletal partners, linking receptor engagement to downstream activation events. Because of these roles in T-cell adhesion and costimulation, CD2 is of long-standing interest in studies of immune synapse formation, lymphocyte activation, and immune modulation.

Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, T-cell surface antigen T11/Leu-5

G11

Anti-CD2 In Vivo Antibody - Low Endotoxin (G11) recognizes Human CD2. Anti-Human CD2 recognizes a cell surface glycoprotein (Mr 45-59 kDa) on human lymphocytes

This monoclonal antibody was purified using Protein A

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.

anti-CD2 In Vivo Antibody - Low Endotoxin (G11) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Western Blot, Functional Assays

Each investigator should determine their own optimal working dilution for specific applications.

Products are for research use only. Not for use in diagnostic or therapeutic procedures.