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Bulk Anti-Human CD11a (38) Antibody

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SKU

ICH1006

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$390.00

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Bulk anti-human CD11a antibody (38)

Product Benefits:

ichorbio's anti-human CD11a antibody (38) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. ichorbio's low endotoxin antibodies have half the endotoxin of comparable antibodies from Bio X Cell at less than 1.0 EU/mg. If ichorbio's low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin (<0.5EU/mg) at an even higher purity (98% versus 95%). ichorbio: the best antibodies for in vivo research.

Target:

CD11a

Clone:

Isotype:

Mouse IgG2a

Other Names:

LFA-1 alpha, LFA-1A, Integrin alpha-L, ITGAL

Uniprot:

P20701

Host:

Mouse

Species Reactivity:

Human

Specificity:

Anti-human CD11a antibody (38) recognizes Human CD11a. Anti-Human CD11a (Anti-LFA-1a) recognizes the (Mr 175 kDa) a chain of the leukocyte function associated antigen-1 (LFA-1). The leukocyte integrin LFA-1 is a member of a family of heterodimeric receptors that mediate divalent cation-dependent cellular adhesion reactions. LFA-1A binds to domain 1 of an intercellular adhesion molecule (ICAM) on target tissues.

Purification Method:

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Antigen Distribution:

The CD11a antigen is present on most leukocytes and plays a vital role in cellular immune responses which require adhesion. Lymphocyte activation via the T-cell antigen receptor (TCR) up-regulates LFA-1 function. The absence of LFA-1A or B may induce the disease state known as leukocyte adhesion deficiency (LAD). Tumor cells which do not express LFA-1 may have avoided cellular immune-responses such as those carried out by natural killer cells (NK).

Background:

Anti-CD11a may be used to study a variety of biological phenomena related to the function of cell adhesion molecules. This antibody may be used to study transplantation rejections and to assist in characterizing lymphomas and leukemias.

Immunogen:

Unknown

Concentration:

1.0 - 5.0 mg/ml

Formulation:

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.

Purity:

>95% by SDS-PAGE and HPLC

>98% by SDS-PAGE and HPLC

Endotoxin:

≤ 1.0 EU/mg as determined by the LAL method

≤ 0.75 EU/mg as determined by the LAL method

Aggregation:

Aggregation level ≤ 5%

Aggregation level ≤ 1%

Storage:

This antibody is stable for at least 4 weeks when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at – 20°C or -80°C. Avoid repeated freeze thaw cycles.

Applications:

Flow Cytometry, Western Blot, IHC (Frozen), Immunofluorescence, Immunoprecipitation

Application Notes:

Each investigator should determine their own optimal working dilution for specific applications.

Use:

Products are for research use only.

Isotype Control:

Mouse IgG2a In Vivo Isotype Control - Low Endotoxin [C1.18.4] (ICH2245)

Antibodies against the same target:

Anti-CD11a In Vivo Antibody - Low Endotoxin [FD441.8] (ICH1047), Anti-CD11a In Vivo Antibody - Low Endotoxin [I21/7] (ICH1048)

More Information
Concentration	1.0 - 5.0 mg/ml
Isotype	Mouse IgG2a
Host	Mouse
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Application Notes	Each investigator should determine their own optimal working dilution for specific applications.
Applications	Flow Cytometry, Western Blot, IHC (Frozen), Immunofluorescence, Immunoprecipitation
Storage	anti-CD11a In Vivo Antibody - Low Endotoxin (38) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at ï؟½80°C. Avoid Repeated Freeze Thaw Cycles.
Endotoxin	≤ 1.0 EU/mg as determined by the LAL method
Purity	>95% by SDS-PAGE and HPLC
Formulation	0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Purification Method	This monoclonal antibody was purified using Protein A
Specificity	Anti-CD11a In Vivo Antibody - Low Endotoxin (38) recognizes Human CD11a. Anti-Human CD11a (Anti-LFA-1a) recognizes the (Mr 175 kDa) a chain of the leukocyte function associated antigen-1 (LFA-1). The leukocyte integrin LFA-1 is a member of a family of het
Species Reactivity	Human
Target	CD11a
Shipping Conditions	Blue ice
background	Anti-CD11a may be used to study a variety of biological phenomena related to the function of cell adhesion molecules. This antibody may be used to study transplantation rejections and to assist in characterizing lymphomas and leukemias.
Other names	LFA-1 alpha, LFA-1A, Integrin alpha-L, ITGAL
clone	38
UniProt	P20701
Buffer	ICH3001-100ml ICH3002-100ml ICH3003-100ml
Antigen Distribution	The CD11a antigen is present on most leukocytes and plays a vital role in cellular immune responses which require adhesion. Lymphocyte activation via the T-cell antigen receptor (TCR) up-regulates LFA-1 function. The absence of LFA-1A or B may induce the
Immunogen	Unknown
Aggregation	Aggregation level ≤ 5%
Antibodies against the same target	Anti-CD11a In Vivo Antibody - Low Endotoxin [FD441.8] (ICH1047), Anti-CD11a In Vivo Antibody - Low Endotoxin [I21/7] (ICH1048)