Natalizumab Biosimilar - Research Grade

Human

CD49d

>1mg/ml

Human IgG4 Kappa

Anti-Mouse CD49d (PS/2) In Vivo Antibody - Low Endotoxin (ICH1200), Vedolizumab Biosimilar - Research Grade (ICH4035)

https://www.imgt.org/mAb-DB/

ICH3001-100ml ICH3002-100ml ICH3003-100ml

P13612

Blue ice

This is a research-grade, unconjugated recombinant analog of natalizumab, a human IgG4 kappa antibody directed against the alpha-4 integrin subunit (CD49d, ITGA4). It reproduces the antigen-binding specificity of the originator molecule but is manufactured strictly for research use only and is not the clinical therapeutic; it is not intended for human or veterinary use. Supplied unconjugated, it is well suited to in-vitro and preclinical work such as blocking and neutralisation assays, competition and epitope-binning studies, flow cytometry and cell-adhesion experiments, and as an isotype-matched or positive-control reagent when characterising anti-CD49d reagents. Because it carries the same variable-region specificity as the reference drug, it is a convenient benchmark for biosimilarity and comparability studies and for developing binding or potency assays. Available at low endotoxin (research grade below 1 EU/mg; ultra-low grade below 0.5 EU/mg) and in bulk milligram-to-gram quantities, it supports assay development, screening campaigns, and preclinical model work requiring consistent lot-to-lot performance. CD49d is the alpha-4 integrin subunit (ITGA4, UniProt P13612). It pairs with the beta-1 subunit (CD29) to form VLA-4 (alpha4beta1) and with the beta-7 subunit to form the alpha4beta7 integrin. VLA-4 binds vascular cell adhesion molecule-1 (VCAM-1) and the CS-1 domain of fibronectin, mediating firm adhesion and transendothelial migration of lymphocytes, monocytes, and other leukocytes across activated endothelium. Alpha4beta7 binds MAdCAM-1 and directs lymphocyte homing to gut-associated mucosal tissue. Through these interactions the alpha-4 integrins govern leukocyte trafficking into inflamed tissue and the central nervous system, and contribute to immune cell activation and retention. Blocking CD49d interrupts leukocyte adhesion and extravasation, which is the rationale underlying alpha-4-directed antibodies in inflammatory and autoimmune research contexts.

ITGA4, CD49D, IA4, integrin subunit alpha 4

Detects human CD49d

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Sterile, preservative-free, solution in PBS. BSA and Azide free.

This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.

Functional Assays

This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.

Products are for research use only. Not for use in diagnostic or therapeutic procedures.