Vedolizumab Biosimilar - Research Grade

Bulk Vedolizumab Biosimilar - Research Grade

Product Specific Citations:

Dipasquale et al. Biosimilars in Pediatric IBD: Updated Considerations for Disease Management. Biologics (2022).

Parrish II et al. Biosimilar Interchangeability and Emerging Treatment Strategies for Inflammatory Bowel Diseases: A Commentary. Gastroenterology Insights (2021).

Product Benefits:

ichorbio's Vedolizumab Biosimilar - Research Grade is manufactured in a cGMP compliant facility. ichorbio: the best antibodies for in vivo research.

Size:

ichorbio's research grade vedolizumab biosimilar is available in the following sizes: 5mg, 10mg, 20mg, 50mg, 100mg ichorbio regularly manufactures bulk multi-gram amounts of our vedolizumab biosimilar - please contact us for pricing.

Target:

Integrin a4b7

Clone:

n/a

Isotype:

IgG1

Other Names:

Integrin Beta 7, Integrin Alpha 4, ITGA4, ITGB7, CD49

Host:

Humanized

Species Reactivity:

Human

Specificity:

Detects human Integrin α4β7.

Purification Method:

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background:

Vedolizumab, an integrin receptor antagonist, is a humanized IgG1 monoclonal antibody produced in Chinese hamster ovary cells that binds to the human α4β7 integrin. Vedolizumab has an approximate molecular weight of 147 kilodaltons.

Concentration:

1.0 - 5.0 mg/ml

Formulation:

Sterile, preservative-free, clear to pale yellow solution, pH 6.3, containing L-histamine Acid, L-histidine monohydrate hydrochloride, L-arginine hydrochloride, sucrose, and polysorbate 80. BSA and Azide free.

Purity:

>95% by SDS-PAGE and HPLC

Endotoxin:

≤ 0.75 EU/mg as determined by the LAL method

Storage:

Vedolizumab Biosimilar - Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Applications:

Functional Assays

Application Notes:

Each investigator should determine their own optimal working dilution for specific applications.

Use: ichorbio's vedolizumab biosimilar is for research use only (RUO).

Isotype Control:

Bulk Human IgG1 Isotype Control (IB1) [ICH2254]