Mecbotamab Biosimilar - Research Grade

Human

AXL

>1mg/ml

IgG1 - kappa

CHO Cells

Tilvestamab Biosimilar - Research Grade (ICH5122), Enapotamab Biosimilar - Research Grade (ICH5522), Mipasetamab Biosimilar - Research Grade (ICH5682)

https://www.imgt.org/mAb-DB/

ICH3002

P30530

Blue ice

This product is an unconjugated, non-therapeutic recombinant analog of the anti-AXL antibody mecbotamab, supplied strictly for research use only. It is a human IgG1 (kappa) directed against the receptor tyrosine kinase AXL (UniProt P30530), reproducing the target specificity of the originator molecule without being the clinical drug and without any conjugated payload or drug linker. Because it is offered in an unconjugated format, it is well suited as a naked binding reagent for characterising AXL engagement and as a matched backbone or benchmark control in antibody-drug conjugate (ADC) development programs where AXL is the target antigen. Typical research applications include AXL-binding and blocking assays, flow cytometry and immunoassay development, receptor internalisation studies, and use as a positive control or reference standard alongside in-house anti-AXL candidates. It is manufactured at research grade with low endotoxin (<1 EU/mg; ultra-low <0.5 EU/mg options) and is available in bulk milligram-to-gram quantities to support screening, preclinical, and assay-scale work. Not for human or veterinary use. AXL is a receptor tyrosine kinase of the TAM family (TYRO3, AXL, MER), encoded by the AXL gene and mapped to UniProt P30530. Its principal ligand is growth arrest-specific 6 (GAS6), which bridges phosphatidylserine on apoptotic-cell and vesicle membranes to the AXL extracellular Ig-like and fibronectin type III domains, driving receptor dimerisation and autophosphorylation. Downstream signalling activates PI3K-AKT, MAPK-ERK, and STAT pathways, promoting cell survival, proliferation, migration, and cytoskeletal remodelling. AXL contributes to efferocytosis, innate-immune regulation, and platelet stabilisation. In oncology it is widely studied as a driver of epithelial-to-mesenchymal transition, metastasis, immune evasion, and acquired resistance to targeted and immune therapies, which makes it an attractive antigen for antibody and ADC approaches.

Tyrosine-protein kinase receptor UFO, Axl oncogene

This monoclonal antibody was purified using Protein A

Sterile, preservative-free, solution in PBS. BSA and Azide free.

This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.

Functional Assays

This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

3-4 weeks