Utomilumab Biosimilar - Research Grade

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ICH5014

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Concentration	5mg/ml
Isotype	Human IgG2-Lambda 2
Host	CHO cells
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Application Notes	This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.
Applications	Functional Assays
Storage	This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.
Endotoxin	≤ 1.0 EU/mg as determined by the LAL method
Purity	>95% by SDS-PAGE
Formulation	Sterile, preservative-free, solution in PBS. BSA and Azide free.
Purification Method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Specificity	Detects human CD137. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Utomilumab.
Species Reactivity	Human
Target	4-1BB
Shipping Conditions	Blue ice
background	RUO Utomilumab is a fully-human IgG2 agonist mAb that selectively binds human 4-1BB/CD137, resulting in NF-_B activation and downstream cytokine production in cell lines and primary lymphocytes. Utomilumab can induce human leukocyte proliferation and has
Other names	4-1BB ligand receptor, T-cell antigen 4-1BB, Tnfrsf9, Ila, Ly63, CD137
UniProt	Q07011
Buffer	ICH3002
Sequence	https://www.imgt.org/mAb-DB/