Manfidokimab Biosimilar - Research Grade

Human

IL4R

>1mg/ml

Human IgG4 - kappa

CHO Cells

Dupilumab Biosimilar - Research Grade (ICH5062), Rademikibart Biosimilar - Research Grade (ICH5271), Stapokibart Biosimilar - Research Grade (ICH5277), Comekibart Biosimilar - Research Grade (ICH5444), Elarekibep Biosimilar - Research Grade (ICH5511)

https://www.imgt.org/mAb-DB/

ICH3002

P24394

Blue ice

This product is an unconjugated, non-therapeutic recombinant analog of manfidokimab, a fully human IgG4-kappa monoclonal antibody directed against the human interleukin-4 receptor alpha subunit (IL4R / IL-4Ralpha, CD124). It is manufactured for research use only and reproduces the antigen-binding specificity of the originator in a format suitable for laboratory work; it is not the clinical drug and is not intended for human or veterinary use. Because IL-4Ralpha is the shared signalling chain of both the type I and type II receptors, an IL-4Ralpha-directed antibody is a convenient single reagent for simultaneously probing IL-4 and IL-13 biology. Typical applications include use as a positive control or benchmark in binding and neutralisation assays, as a capture or detection reagent, as a tool for characterising IL-4Ralpha expression, and in antibody-engineering or biosimilarity workflows. The antibody is offered as low-endotoxin, carrier-free material (research grade <1 EU/mg; ultra-low <0.5 EU/mg) and is available in bulk milligram-to-gram quantities to support in-vitro assay development and preclinical model standardisation. Interleukin-4 receptor subunit alpha (IL-4Ralpha, CD124; UniProt P24394) is the high-affinity ligand-binding chain shared across IL-4 and IL-13 signalling. In the type I receptor, IL-4Ralpha pairs with the common gamma chain (gamma-c) and responds to IL-4, predominantly on haematopoietic cells. In the type II receptor, IL-4Ralpha pairs with IL-13Ralpha1 and responds to both IL-4 and IL-13, chiefly on non-haematopoietic and myeloid cells. Ligand engagement activates JAK1/JAK3 (type I) or JAK1/JAK2/TYK2 (type II) and drives STAT6 phosphorylation, with IRS-2/PI3K contributions. This axis governs Th2 differentiation, IgE class switching, goblet-cell and mucus responses, and M2 macrophage polarisation, making IL-4Ralpha a central node in type 2 (allergic) inflammation and fibrosis.

IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha, IL-4RA, Interleukin-4 receptor subunit alpha

Detects human IL4R

This monoclonal antibody was purified using Protein A

Sterile, preservative-free, solution in PBS. BSA and Azide free.

This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.

Functional Assays

This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

4 weeks