Mosunetuzumab Biosimilar - Research Grade

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SKU

ICH5026

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Mosunetuzumab Biosimilar - Research Grade

Product Details:

ichorbio's mosunetuzumab biosimilar is for Research Use Only (RUO)

Size:

ichorbio's RUO mosunetuzumab biosimilar is available in the following sizes: 1mg, 5mg, 10mg, 20mg ichorbio regularly manufactures bulk multi-gram amounts of this biosimilar - please contact us for pricing.

Target:

CD3e/CD20

Isotype:

Bispecific

Other Names:

BTCT4465A

Host:

CHO cells

Species Reactivity:

Human

Specificity:

Detects human CD3/CD20.

Purification Method:

This recombinant protein was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background:

ichorbio's Mosunetuzumab biosimilar is a bispecific, humanized monoclonal antibody with potential antineoplastic activity. Anti-CD20/CD3 bispecific monoclonal antibody BTCT4465A contains two antigen-recognition sites: one for human CD3, a T-cell surface antigen, and one for human CD20, a tumor-associated antigen (TAA) that is exclusively expressed on B cells during most stages of B-cell development and is often overexpressed in B-cell malignancies. Upon administration, BTCT4465A binds to both T cells and CD20-expressing tumor B cells; this cross-links T cells to tumor cells, and may result in a potent cytotoxic T-lymphocyte (CTL) response against CD20-expressing tumor B cells..

Concentration:

1.0 - 5.0 mg/ml

Formulation:

Sterile, preservative-free, solution in PBS. BSA and Azide free.

Purity:

>95% by SDS-PAGE and HPLC

Endotoxin:

≤ 1.0 EU/mg as determined by the LAL method

Storage:

Mosunetuzumab biosimilar - Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Applications:

Functional Assays

Application Notes:

Each investigator should determine their own optimal working dilution for specific applications.

Use: ichorbio's mosunetuzumab biosimilar is for research use only (RUO). Isotype Control:

Bulk Human IgG1 Isotype Control (IB1) [ICH2254]

More Information
Concentration	14.3mg/ml
Isotype	Bispecific
Host	CHO cells
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Application Notes	This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.
Applications	Functional Assays
Storage	This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.
Endotoxin	≤ 1.0 EU/mg as determined by the LAL method
Purity	>90% by SDS-PAGE
Formulation	Sterile, preservative-free, solution in PBS. BSA and Azide free.
Purification Method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Specificity	Detects human CD3/CD20. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Mosunetuzumab.
Species Reactivity	Human
Target	CD3e + CD20
Shipping Conditions	Blue ice
background	ichorbioï؟½s Mosunetuzumab biosimilar is a bispecific, humanized monoclonal antibody with potential antineoplastic activity. Anti-CD20/CD3 bispecific monoclonal antibody BTCT4465A contains two antigen-recognition sites: one for human CD3, a T-cell surface
Other names	BTCT4465A
UniProt	P07766
Buffer	ICH3002
Sequence	https://www.imgt.org/mAb-DB/