Tilvestamab Biosimilar - Research Grade

Human

Axl

>1mg/ml

Human IgG1 Kappa

Enapotamab Biosimilar - Research Grade (ICH5522), Mecbotamab Biosimilar - Research Grade (ICH5675), Mipasetamab Biosimilar - Research Grade (ICH5682)

https://www.imgt.org/mAb-DB/

ICH3002

P30530

Blue ice

This product is a research-grade, unconjugated recombinant analog of tilvestamab, a humanized IgG1 kappa antibody directed against the receptor tyrosine kinase AXL (UniProt P30530). It is a non-therapeutic biosimilar intended strictly for research use only (RUO) and is not the clinical drug, nor is it for human or veterinary use. Because it reproduces the antigen-binding specificity of the originator against human AXL, it is a convenient tool for in-vitro and preclinical investigation of AXL biology, GAS6/AXL signaling, and receptor-blocking pharmacology. Typical applications include positive and reference controls in binding and neutralization assays, benchmarking of new anti-AXL candidates, ADCC or antibody-drug-conjugate development workpackages, epitope and mechanism studies, and target-engagement readouts. The material is supplied at research grade with low endotoxin (<1 EU/mg; ultra-low <0.5 EU/mg options), is available in bulk milligram-to-gram quantities, and can serve as an in-vivo-grade standard where appropriate. No clone designation is implied; the reagent is defined by its AXL target specificity and human IgG1 kappa framework. AXL (tyrosine-protein kinase receptor UFO; UniProt P30530) is a member of the TAM family of receptor tyrosine kinases, alongside TYRO3 and MER. Its principal ligand is the vitamin-K-dependent protein GAS6, whose binding drives AXL dimerization and autophosphorylation. Activated AXL recruits PI3-kinase regulatory subunits, GRB2, PLCG1 and PTPN11, engaging downstream AKT, MAPK and STAT signaling that regulates cell survival, proliferation, migration, adhesion and immune modulation. AXL overexpression and aberrant activation are linked to epithelial-mesenchymal transition, tumor invasion, metastasis and acquired resistance to targeted and cytotoxic therapies across multiple cancers. AXL also contributes to innate immune regulation and efferocytosis, and has been reported as an entry cofactor for certain enveloped viruses via GAS6-mediated phosphatidylserine bridging. These roles make AXL an actively studied oncology and immunology target.

Tyrosine-protein kinase receptor UFO, Axl oncogene

Detects human Axl

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Sterile, preservative-free, solution in PBS. BSA and Azide free.

This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.

Functional Assays

This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.

Products are for research use only. Not for use in diagnostic or therapeutic procedures.