Mouse Anti-Mouse PD-1 Antibody (RMP1-14) D265A
ichorbio’s mouse anti-mouse PD-1 antibody (RMP1-14) D265A is manufactured in a cGMP compliant facility. ichorbio: the best antibodies for in vivo research.
ICH1182D265A mouse anti-mouse RMP1-14 is available in the following sizes:
5mg, 10mg, 20mg and 50mg
Programmed cell death protein 1, Pdcd1, CD279
Mouse anti-mouse PD-1 antibody (RMP1-14) recognizes an epitope on Mouse PD-1. ICH1182D265A contains a mutation at D265A to reduce its effector function.
This recombinant antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Subset of double negative thymocytes, activated T and B cells
CD279, also known as programmed death-1 (PD-1) is a 50-55 kD immunoglobulin superfamily member. PD-1 is expressed on a subset of CD4-CD8- thymocytes, and on activated T and B cells. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. This RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production.
Mouse PD-1 transfected BHK cells
1.0 – 5.0 mg/ml
0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.
>95% by SDS-PAGE and HPLC
>98% by SDS-PAGE and HPLC
≤ 1.0 EU/mg as determined by the LAL method
≤ 0.75 EU/mg as determined by the LAL method
Mouse anti-mouse PD-1 antibody (RMP1-14) is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -70oC.
Western Blot, Blocking, Flow Cytometry, Functional Assays
Products are for research use only. Not for use in diagnostic or therapeutic procedures.