Marmoset FcRn heterodimer Protein

Marmoset (Callithrix jacchus)

Marmoset FcRn heterodimer Protein

Human embryonic kidney (HEK) 293 cells

U3CHJ4 / P63061

Ambient

FcRn maintains IgG and albumin levels through pH-dependent recycling across mammals, and a marmoset reagent supports antibody pharmacokinetic research in this non-human-primate model. This recombinant marmoset FcRn heterodimer, built from the alpha chain and beta-2-microglobulin, is expressed in HEK 293 cells and validated for SPR, BLI and ELISA to enable pH-dependent IgG binding studies. It is supplied for research use only in an in vivo grade, ultra-low-endotoxin format and produced in scalable milligram (mg) to gram (g) quantities, giving bulk and high-throughput laboratories a dependable primate FcRn tool for pharmacokinetics and Fc engineering work.

FcRn, FCGRT, FCGRT & B2M, FCGRT and B2M, Neonatal Fc receptor, Neonatal receptor, Brambell receptor

The sequence of the extracellular domain of marmoset FCGRT (Ala 24-Ser 297) was fused with a C-terminal tag consisting of the AVI tag, TEV protease recognition sequence and a 10-His tag. This was co-transfected with the sequence of marmoset B2M (Ile 21-Ile 119) and the resulting FcRn heterodimer was purified. The full protein sequences can be downloaded from the product webpage.

Lyophilized from sterile PBS, pH 7.4. No preservatives or cryoprotectants have been added. To obtain a final concentration of 1 mg/ml reconstitute 0.25 mg vials with 0.25 ml water and 1.0 mg vials with 1.0 ml water.

Lyophilized proteins are stable at ambient temperature for at least 2 weeks. If the protein is not to be used immediately then the protein should be stored in lyophilized form at -20 °C for up 12 months. Once the protein has been reconstituted we recommen

SPR, BLI, ELISA

Products are for research use only. Not for use in diagnostic or therapeutic procedures.