Enibarcimab Biosimilar - Research Grade

Human

ADM

>1mg/ml

Human IgG1 (E356D/M358L)-kappa

https://www.imgt.org/mAb-DB/

ICH3002

P35318

Blue ice

This is a research-grade, unconjugated recombinant analog of enibarcimab (formerly adrecizumab), an antibody built around human adrenomedullin (ADM). It is a non-therapeutic biosimilar intended for research use only (RUO) and is not the clinical drug; it is not for human or veterinary use. The molecule is a full-length human IgG1-kappa (carrying the E356D/M358L allotype substitutions in the Fc) that recognizes the ADM peptide, making it a useful tool reagent for target-engagement studies, standard curves, positive/isotype-matched controls, assay development, and in-vitro and preclinical characterization of ADM biology. Because it reproduces the antigen-binding behavior of the originator without therapeutic intent, researchers can use it to benchmark binding, screen assay formats, and support ADCC/ADC-development-style workflows independent of a clinical supply. It is supplied unconjugated to preserve flexibility for downstream labeling or immobilization. Material is offered at research grade with low endotoxin (typically <1 EU/mg, with ultra-low <0.5 EU/mg options) and in bulk milligram-to-gram quantities suitable for in-vivo-standard and large-format experiments. Adrenomedullin (ADM; gene ADM, UniProt P35318) is a 52-amino-acid vasoactive peptide derived from preproadrenomedullin, which is also processed to proadrenomedullin N-terminal 20 peptide (PAMP). ADM belongs to the calcitonin/CGRP peptide family and signals through the calcitonin receptor-like receptor (CALCRL) in complex with receptor activity-modifying proteins RAMP2 and RAMP3, driving cAMP production. It is produced by vascular endothelial and smooth muscle cells and many other tissues, and is a key regulator of vascular tone and, importantly, endothelial barrier integrity. ADM promotes vasodilation, counteracts vascular leakage, and has roles in blood pressure control, cardiovascular homeostasis, and the response to inflammatory and septic insults. Circulating bioactive ADM is a recognized biomarker of endothelial dysfunction; both excess and dysregulated ADM signaling are implicated in septic shock, heart failure, and other critical illness.

Pro-adrenomedullin, AM

Detects human ADM

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Sterile, preservative-free, solution in PBS. BSA and Azide free.

This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.

Functional Assays

This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.

Products are for research use only. Not for use in diagnostic or therapeutic procedures.