Edrecolomab Biosimilar - Research Grade

Human

CD326

>1mg/ml

Mouse IgG2a Kappa

Adecatumumab Biosimilar - Research Grade (ICH5328)

https://www.imgt.org/mAb-DB/

ICH3002

P16422

Blue ice

This is a research-grade, unconjugated recombinant analog of edrecolomab, offered strictly for research use (RUO) and not as the therapeutic product. Edrecolomab (originally known as 17-1A) is a murine IgG2a antibody directed against the epithelial cell adhesion molecule EpCAM (CD326), a surface antigen broadly expressed on carcinoma cells. This biosimilar recreates the binding specificity around the CD326 target on a mouse IgG2a kappa framework, making it a convenient reagent for antigen-binding studies, EpCAM detection, and as a benchmarking or positive-control tool in assay development. Because it is a well-characterized murine IgG2a, it is useful for exploring Fc-dependent effector activity such as antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity against EpCAM-positive cells in vitro, and for antibody-engineering or ADC-development workflows that need a defined anti-EpCAM binder. The material is supplied unconjugated at low endotoxin, in bulk milligram-to-gram quantities suitable for in-vitro standards, screening, and preclinical model work. It is not intended for human or veterinary use. CD326, better known as EpCAM (epithelial cell adhesion molecule; gene TACSTD1, UniProt P16422), is a type I transmembrane glycoprotein expressed on the basolateral surface of most simple, pseudostratified, and transitional epithelia. Despite its name, EpCAM mediates weak, homotypic cell-cell adhesion and can antagonize classical cadherin-based junctions. It has an important signaling role: regulated intramembrane proteolysis releases its intracellular domain (EpICD), which associates with FHL2, beta-catenin, and Lef-1 to drive transcription of proliferation-associated genes such as c-myc and cyclins. EpCAM is markedly overexpressed on many carcinomas (colorectal, breast, gastric, and others) and is a marker of certain epithelial progenitor and stem cells, making it a long-standing target for tumor detection, circulating tumor cell capture, and antibody-based therapeutic strategies.

Ep-CAM, Adenocarcinoma-associated antigen, Cell surface glycoprotein Trop-1, Epithelial cell surface antigen, Epithelial glycoprotein, EGP, Epithelial glycoprotein 314, EGP314, hEGP314, KS 1/4 antigen, KSA, Major gastrointestinal tumor-associated protein

Detects human CD326

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Sterile, preservative-free, solution in PBS. BSA and Azide free.

This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.

Functional Assays

This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.

Products are for research use only. Not for use in diagnostic or therapeutic procedures.