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Anti-IFN Beta (HDB-4A7) In Vivo Antibody - Low Endotoxin
$400.00 - $3,780.00
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Bulk anti-IFN beta In Vivo Antibody - Low Endotoxin (HDB-4A7)
Endotoxin
≤ 1.0 EU/mg as determined by the LAL method
Purity
>95% by SDS-PAGE and HPLC
Product Specific Citations
Species Reactivity
Mouse
Target
IFN beta
Concentration
1.0 - 5.0 mg/ml
Isotype
Mouse IgG2a
Host
Mouse
Use
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Application Notes
Blocking: Blocks in vivo IFNb leading to increased the lethality of mice infected with West Nile Virus (WNV), similar to the susceptibility of IFNb-/- mice. Clone HDB-4A7 circulates with a half-life of ~ 14 days.
Each investigator should determine their own optimal working dilution for specific applications.
Applications
Western Blot, Blocking, Functional Assays
Storage
anti-IFN beta In Vivo Antibody - Low Endotoxin (HDB-4A7) is stable when stored at 2-8°C. Do not freeze. For long term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Formulation
0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Purification Method
This monoclonal antibody was purified using Protein A
Specificity
Anti-IFN beta In Vivo Antibody - Ultra Low Endotoxin (HDB-4A7) recognizes an epitope on Mouse IFN-beta and binds specifically to murine IFNbeta and does not bind murine IFNg or several different IFNa species (a-1,4,5 or 13); HDb-4A7 binds both recombinant and natural forms
Shipping Conditions
Blue ice
Background
Interferon beta is a type I interferon that establishes antiviral states, modulates innate immune signalling and influences inflammatory responses. Clone HDB-4A7 is a mouse IgG2a monoclonal antibody to mouse IFN beta, validated for Western blot, blocking and functional assays. Anti-IFN beta HDB-4A7 is supplied in a low-endotoxin, in-vivo-suitable format and produced in scalable milligram (mg) to gram (g) quantities for bulk and high-throughput laboratories. This non-therapeutic, research-use-only (RUO) reagent delivers reproducible performance for studies of type I interferon biology in the mouse, with consistent lot-to-lot quality suited to demanding, large-scale workflows.
Other Names
IFN-b, IFN-beta, Type-1 interferon, Interferon beta
Clone
HDB-4A7
Uniprot
P01575
Buffer
ICH3001-100ml
ICH3002-100ml
ICH3003-100ml
Immunogen
Plasmid DNA encoding murine IFNb
Aggregation
Aggregation level ≤ 5%
Antibodies Against The Same Target
More Information
Bio X Cell:
ICH1110 is up to 37% cheaper for industry than the equivalent product BE0102 from Bio X Cell.
Product Benefits:
ichorbio's anti-IFN beta In Vivo Antibody - Low Endotoxin (HDB-4A7) is manufactured in a cGMP compliant. ichorbio's low endotoxin antibodies have half the endotoxin of comparable antibodies from Bio X Cell at less than 1.0 EU/mg. If ichorbio's low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin (<0.5EU/mg) at an even higher purity (98% versus 95%). ichorbio: the best antibodies for in vivo research.
Size:ichorbio's HDB-4A7 in vivo antibody is available in the following bulk sizes: 1mg, 5mg, 25mg, 50mg and 100mg ichorbio regularly manufactures multi-gram amounts of our anti-interferon beta HDB-4A7 clone - please contact us for pricing.
Isotype Control:Mouse IgG2a In Vivo Isotype Control - Low Endotoxin [C1.18.4] (ICH2245)
Antibodies against the same target:Anti-IFN beta In Vivo Antibody - Low Endotoxin [MIB-5E9.1] (ICH1124)
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