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Anti-Mouse IFNAR1 (MAR1-5A3) In Vivo Antibody - Low Endotoxin
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Anti-Mouse IFNAR1 (MAR1-5A3) In Vivo Antibody - Low Endotoxin
| Concentration | ≤ 2.0 mg/ml |
|---|---|
| Isotype | Mouse IgG1 |
| Host | Mouse |
| Use | Products are for research use only. Not for use in diagnostic or therapeutic procedures. |
| Application Notes | Blocking: Clone MAR1-5A3 has a short half-life, basically because every cell expresses the IFNAR1 receptor and the receptor recycles very rapidly. And, if you want to block function in vivo, you need to be sure that all of the receptors are blocked contin |
| Applications | Immunoprecipitation, Western Blot, Blocking, Functional Assays, Flow Cytometry, ELISA |
| Storage | anti-IFNAR1 In Vivo Antibody - Low Endotoxin (MAR1-5A3) is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at ï؟½80°C in a manual defrost freezer. |
| Endotoxin | ≤ 1.0 EU/mg as determined by the LAL method |
| Purity | >95% by SDS-PAGE and HPLC |
| Formulation | 0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added. |
| Purification Method | This monoclonal antibody was purified using Protein A |
| Specificity | Anti-IFNAR1 In Vivo Antibody - Low Endotoxin (MAR1-5A3) recognizes the extracellular domain of the IFNAR1 subunit of the mouse IFN-alpha / beta receptor. |
| Species Reactivity | Mouse |
| Target | IFNAR1 |
| Shipping Conditions | Blue ice |
| background | The antibody when prepared specifically for In vivo functional assays blocks type I IFN receptor signaling both In vitro and In vivo without depleting IFNAR1 bearing cells. This antibody was produced by In vivo genetic immunization of IFNAR1 knockout mice |
| Other names | Interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, Type I interferon receptor 1, Ifar, Ifnar |
| clone | MAR1-5A3 |
| UniProt | P33896 |
| Buffer | ICH3001-100ml ICH3002-100ml ICH3003-100ml |
| Antigen Distribution | IFNAR1 and IFNAR2 are coexpressed on nearly all cells. |
| Immunogen | This antibody was produced by In vivo genetic immunization of IFNAR1 knockout mice with a plasmid encoding the extracellular domain of murine IFNAR1. |
| Aggregation | Aggregation level ≤ 5% |
| Related Antibody | Anti-IFNAR1 In Vivo Antibody - Ultra Low Endotoxin [MAR1-5A3] (ICH1122UL) |
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