Aducanumab Biosimilar - Research Grade

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SKU

ICH5008

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Aducanumab Biosimilar - Research Grade

Product Details:

ichorbio's aducanumab biosimilar is for Research Use Only (RUO)

Size:

ichorbio's RUO aducanumab biosimilar is available in the following sizes: 1mg, 5mg, 10mg, 20mg, 50mg, 100mg ichorbio regularly manufactures bulk multi-gram amounts of this biosimilar - please contact us for pricing.

Target:

Amyloid Beta

Isotype:

IgG1 kappa

Other Names:

Aducanumab-avwa, BIIB037, BIIB-037

Host:

CHO cells

Species Reactivity:

Human

Specificity:

Detects human amyloid beta.

Purification Method:

This recombinant protein was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background:

RUO Aducanumab is a human monoclonal antibody that selectively targets aggregated amyloid beta. In a transgenic mouse model of Alzheimer's disease, aducanumab is shown to enter the brain, bind parenchymal amyloid beta, and reduce soluble and insoluble amyloid beta in a dose-dependent manner.

Concentration:

1.0 - 5.0 mg/ml

Formulation:

Sterile, preservative-free, solution in PBS. BSA and Azide free.

Purity:

>95% by SDS-PAGE and HPLC

Endotoxin:

≤ 1.0 EU/mg as determined by the LAL method

Storage:

Aducanumab Biosimilar - Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Applications:

Functional Assays

Application Notes:

Each investigator should determine their own optimal working dilution for specific applications.

Use: ichorbio's aducanumab biosimilar is for research use only (RUO).

More Information
Concentration	9.05mg/ml
Isotype	IgG1 kappa
Host	CHO cells
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Application Notes	This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.
Applications	Functional Assays
Storage	This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.
Endotoxin	≤ 1.0 EU/mg as determined by the LAL method
Purity	>95% by SDS-PAGE
Formulation	Sterile, preservative-free, solution in PBS. BSA and Azide free.
Purification Method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Specificity	Detects human Beta Amyloid. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Aducanumab.
Species Reactivity	Human
Target	Beta Amyloid
Shipping Conditions	Blue ice
background	RUO Aducanumab is a human monoclonal antibody that selectively targets aggregated amyloid beta. In a transgenic mouse model of Alzheimerï؟½s disease, aducanumab is shown to enter the brain, bind parenchymal amyloid beta, and reduce soluble and insoluble a
Other names	Aducanumab-avwa, BIIB037, BIIB-037
UniProt	P05067
Buffer	ICH3002
Sequence	https://www.imgt.org/mAb-DB/