Rat IgG2a (1-1) In Vivo Isotype Control Low Endotoxin

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ICH2244

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Rat IgG2a (1-1) In Vivo Isotype Control Low Endotoxin

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Product Specific Citations	Chuah, S. et al. Uncoupling immune trajectories of response and adverse events from anti-PD-1 immunotherapy in hepatocellular carcinoma. Journal of Hepatology. Volume 77, Issue 3, 2022, Pages 683-694, Benguigui et al. Interferon-stimulated neutrophils as a predictor of immunotherapy response. 2024, Cancer Cell 42, 253–265 Roichman et al. Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models. Cancer Res 2025 Braun, Lukas M. et al. Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity Cancer Cell, Volume 43, Issue 2, 269 - 291.e19 Patel, A. et al. Targeting Neuronal Nitric Oxide Synthase (nNOS) as a Novel Approach to Enhancing the Anti-Melanoma Activity of Immune Checkpoint Inhibitors. Pharmaceutics 2025, 17, 691. Liang B. et al. Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy. Front Oncol. 2024 Oct 14;14:1441935. Liang B. et al. SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression. Cancer Research Communications (2023) 3 (11): 2412–2419. PD-1 Blockade Restores the Proliferation of Peripheral Blood Lymphocyte and Inhibits Lymphocyte Apoptosis in a BALB/c Mouse Model of CP BVDV Acute Infection Benguigui et al. Interferon-stimulated neutrophils as a predictor of immunotherapy response. Cancer Cell. 4:S1535-6108(23)00433-6. Chuah et al. Uncoupling immune trajectories of response and adverse events from anti-PD-1 immunotherapy in hepatocellular carcinoma. Journal of Hepatology (2022) Liu et al. PD-1 Blockade Restores the Proliferation of Peripheral Blood Lymphocyte and Inhibits Lymphocyte Apoptosis in a BALB/c Mouse Model of CP BVDV Acute Infection. Frontiers in Immunology (2021)
Concentration	1.0 - 5.0 mg/ml
Isotype	IgG2a
Host	Rat
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Application Notes	This isotype control antibody should be used at the same concentration as the primary antibody.
Storage	This Low Endotoxin Functional Formulation is stable when stored at 2-8°C. Do not freeze.
Endotoxin	≤ 1.0 EU/mg as determined by the LAL method
Purity	>95% by SDS-PAGE and HPLC
Formulation	This Low Endotoxin Functional Formulation antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Purification Method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Specificity	This Rat IgG2a isotype control (anti-Trinitrophenol + KLH) antibody has been tested against selected species' cells and tissues to assure minimal cross reactivity.
Target	KLH
Shipping Conditions	Blue ice
clone	1-1
Buffer	ICH3001-100ml ICH3002-100ml ICH3003-100ml
Aggregation	Aggregation level ≤ 5%

Bio X Cell:

ichorbio's rat IgG2a isotype control is up to 37% cheaper for industry than the equivalent low endotoxin version from Bio X Cell (BE0089). ICH2244UL is up to 36% cheaper for industry compared to Bio X Cell's ultra-low endotoxin version (BP0089).

Product Benefits:

ichorbio’s anti-Rat IgG2a isotype control is manufactured in a cGMP compliant facility.

If ichorbio’s low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin (<0.5EU/mg) at an even higher purity (98% versus 95%).

ichorbio: the best antibodies for in vivo research.

IMPACT Pathogen Test:

We use the IMPACT test generated by IDEXX Laboratories to guarantee our Ultra Low Endotoxin antibodies are pathogen free. Our rat antibodies are tested for: Mycoplasma spp Mycoplasma pulmonis Pneumonia virus of mice Kilham's rat virus Toolan's H1 virus Rat parvovirus Lymphocytic choriomeningitis virus Rat cytomegalovirus Sendai virus Rat coronavirus Sialodacryoadenitis virus Rat minute virus Seoul virus Mouse adenovirus Reovirus 3 Rat theilovirus

Applications:

This Rat IgG2a isotype control antibody should be used at the same concentration as the primary antibody.

Use:

Products are for research use only.

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