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Anti-Mouse Galectin-9 (RG9-1) In Vivo Antibody - Low Endotoxin

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SKU

ICH1186

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$390.00

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Anti-Mouse Galectin-9 In Vivo Antibody - Low Endotoxin (RG9-1)

Bio X Cell:

ICH1186 is up to 37% cheaper for industry than the equivalent product BE0218 from Bio X Cell.

Product Benefits:

ichorbio's Anti-Mouse Galectin-9 In Vivo Antibody - Low Endotoxin (RG9-1) [ICH1186] is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. ichorbio's low endotoxin antibodies have half the endotoxin of comparable antibodies from Bio X Cell at less than 1.0 EU/mg. If ichorbio's low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin (<0.5EU/mg) at an even higher purity (98% versus 95%). ichorbio: the best antibodies for in vivo research.

Target:

Galectin-9

Clone:

RG9-1

Size:

ichorbio's RG9-1 in vivo antibody is available in the following bulk sizes: 5mg, 25mg, 50mg and 100mg. ichorbio regularly manufactures multi-gram amounts of our anti-mouse Galectin-9 RG9-1 clone - please contact us for pricing.

Isotype:

IgG2b kappa

Other Names:

Gal-9

Host:

Rat

Species Reactivity:

Mouse

Antigen Distribution:

Galectin-9 is expressed by many cell types, including T cells, B cells, macrophages, dendritic cells, astrocytes, mast cells, eosinophils, fibroblasts, endothelial cells, and epithelial cells.

Background:

Galectin-9 (Gal-9), a member of the galectin family of mammalian lectins, binds β-galactoside. Gal-9 is expressed by many cell types, including endothelial cells, the epithelium of the gastrointestinal tract, T cells, B cells, macrophages, and mast cells. Gal-9 plays a significant role in innate and adaptive immunity and regulates excessive immunity by suppressing interleukin (IL)-17 producing effector T helper cells (Th)17 and Th1 as well as by augmenting Foxp3+ regulatory T cells (Treg). In addition, Gal-9 induces monocytic myeloid-derived suppressor cells (MDSCs), granulocytic MDSCs, and plasmacytoid dendritic cell-like macrophages. Gal-9 also suppresses B cell receptor signaling and is regulated by I-branching of N-glycans. Additionally, Gal-9 stimulates the maturation of dendritic cells.

Gal-9 is thought to function by binding to specific carbohydrate moieties in receptor molecules expressed on the surface of its target cells, including the T-cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3). Gal-9 is predominantly located in the cytoplasm but can also be secreted. Gal-9 is expressed by a variety of tumor cells, plays a role in tumor immunity, and can suppress tumor metastasis by blocking adhesion to endothelium and extracellular matrices. CD45, which regulates antigen receptor signaling, is a major glycoprotein receptor for Gal-9 on naive B cells. Concentration:

1.0 - 5.0 mg/ml

Formulation:

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.

Purity:

>95% by SDS-PAGE and HPLC

>98% by SDS-PAGE and HPLC

Endotoxin:

<1.0 EU/mg as determined by the LAL method

≤ 0.75 EU/mg as determined by the LAL method

Aggregation:

Aggregation level ≤ 5%

Aggregation level ≤ 1%

IMPACT Pathogen Test:

We use the IMPACT test generated by IDEXX Laboratories to guarantee our Ultra Low Endotoxin antibodies are pathogen free. Our mouse antibodies are tested for: Mycoplasma spp., Mycoplasma pulmonis, Sendai virus, Mouse hepatitis virus, Pneumonia virus of mice, Minute virus of mice, Mouse parvovirus (MPV1-5), Theiler's murine encephalomyelitis virus, Murine norovirus, Reovirus 3, Mouse rotavirus, Ectromelia virus, Lymphocytic choriomeningitis virus, Polyoma virus, Lactate dehydrogenase-elevating virus, Mouse adenovirus (MAD1, MAD2), Mouse cytomegalovirus K virus, Mouse thymic virus, Hantaan virus, Corynebacterium bovis, Corynebacterium spp. (HAC2)

Storage:

Anti-mouse Galectin-9 In Vivo Antibody - Low Endotoxin (RG9-1) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Applications:

Blocking

Application Notes:

Each investigator should determine their own optimal working dilution for specific applications..

Use:

Products are for research use only.

Isotype Control:

Rat IgG2b In Vivo Isotype Control – Low Endotoxin (1-2) [ICH2243]

More Information
Concentration	≤ 5.0 mg/ml
Isotype	IgG2b kappa
Host	Rat
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Applications	Blocking
Storage	This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at ï؟½80°C. Avoid Repeated Freeze Thaw Cycles.
Endotoxin	<1.0 EU/mg as determined by the LAL method
Purity	≥95% monomer by analytical SEC, >95% by SDS Page
Formulation	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Purification Method	This monoclonal antibody was purified using Protein G
Specificity	RG9-1 activity is directed against mouse galectin-9
Species Reactivity	Mouse
Target	Galectin-9
Shipping Conditions	Blue ice
background	Galectin-9 (Gal-9), a member of the galectin family of mammalian lectins, binds _-galactoside. Gal-9 is expressed by many cell types, including endothelial cells, the epithelium of the gastrointestinal tract, T cells, B cells, macrophages, and mast cells.
Other names	Gal-9
clone	RG9-1
UniProt	https://www.uniprot.org/uniprot/O08573
Buffer	ICH3001-100ml ICH3002-100ml ICH3003-100ml
Antigen Distribution	Galectin-9 is expressed by many cell types, including T cells, B cells, macrophages, dendritic cells, astrocytes, mast cells, eosinophils, fibroblasts, endothelial cells, and epithelial cells
Immunogen	Recombinant mouse galectin-9
Aggregation	Aggregation level ≤ 5%