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Ant-Human LAG-3 (IB18) Antibody
Endotoxin
<1EU/mg Determined by LAL gel clotting assay
Purity
≥95% monomer by analytical SEC, >95% by SDS Page
Species Reactivity
Human
Target
LAG3
Concentration
5mg/ml
Isotype
Human IgG4 S228P Kappa
Size
0.1mg
Uniprot
P18627
Shipping Conditions
Blue ice
Background
LAG-3 (CD223) is an inhibitory checkpoint receptor expressed on activated T cells, where it restrains effector responses and contributes to T-cell exhaustion in tumours. Clone IB18 is a human IgG4 (S228P) monoclonal antibody recognising human LAG-3, suitable for functional assays probing checkpoint engagement and T-cell regulation. Anti-LAG-3 clone IB18 is prepared in a low-endotoxin format compatible with in vivo use and is manufactured in scalable milligram (mg) to gram (g) quantities for bulk and high-throughput laboratories. Supplied for research use only as a non-therapeutic reagent, IB18 delivers consistent, lot-to-lot reproducible performance for immuno-oncology research.
Specificity
Detects human LAG3
Purification Method
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Formulation
Sterile, preservative-free, solution in PBS. BSA and Azide free.
Storage
This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.
Application Notes
This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.
Use
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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