in vivo research

The field of cancer immunotherapy has witnessed remarkable advancements in recent years, with immune checkpoint inhibitors (ICIs) at the forefront of this revolution. However, as the limitations of ICIs become...

Introduction

The latest study about the role of autoantigen-specific CD4+ T cell phenotypes in several autoimmune diseases opens a new...

The field of cancer immunotherapy has witnessed remarkable advancements in recent years, with immune checkpoint inhibitors emerging as a revolutionary approach to treating various malignancies. Among...

Introduction

A recent revolutionary study in the journal ACS Nano presents a novel immunotherapy approach to treating haematological...

Abstract:

Neutrophils play a critical role in the innate immune response but their dysregulated recruitment and activation can drive tissue damage in chronic inflammatory conditions. This review examines current understanding of the molecular mechanisms regulating...

Introduction

Regulatory T cells (Tregs) play a crucial role in maintaining immune homeostasis and preventing autoimmunity. However, in certain contexts, such as cancer immunotherapy, the suppressive function of Tregs can hinder effective immune responses against tumors. Targeting...

Introduction

The tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as 4-1BB or CD137, has emerged as a promising target for cancer immunotherapy. This costimulatory receptor, primarily expressed on activated T cells and natural killer (NK) cells, plays a crucial role in enhancing...

1. Introduction

Dendritic cells (DCs) are crucial immune system components, acting as primary antigen-presenting cells that bridge the innate and adaptive immune responses [1]. Depleting dendritic cells in vivo is a standard experimental technique to study...

1. Understanding CD8+ T Cell Depletion

The fall or removal of CD8+ T cells, a form of T cell depletion, leads to the recognition and eradicating of various abnormal cells, virally infected cells, and tumor cells because CD8+ T cells are essential components of the immune defense system [1]. There are several ways to eliminate T cells, but antibody-based depletion has become a breakthrough in the respective...