in vivo research

B-cells play a paradoxical role in preclinical disease models. In autoimmune diseases like Systemic Lupus Erythematosus (SLE) and Multiple Sclerosis (EAE), they are the primary pathogenic drivers. In immuno-oncology, their presence in the Tumor Microenvironment (TME) can...

Vascular Endothelial Growth Factor (VEGF) is a primary driver of tumor angiogenesis. However, its role extends far beyond simply building new blood vessels to feed a growing tumor. VEGF is a potent immunosuppressor within the tumor microenvironment (TME), actively hindering dendritic...

The therapeutic monoclonal antibody landscape has expanded dramatically over the past decades, driven by our deepening understanding of immunoglobulin biology and advances in protein...

The field of cancer immunotherapy has witnessed remarkable advancements in recent years, with immune checkpoint inhibitors (ICIs) at the forefront of this revolution. However, as the limitations of ICIs become...

Introduction

The latest study about the role of autoantigen-specific CD4+ T cell phenotypes in several autoimmune diseases opens a new...

The field of cancer immunotherapy has witnessed remarkable advancements in recent years, with immune checkpoint inhibitors emerging as a revolutionary approach to treating various malignancies. Among...

Introduction

A recent revolutionary study in the journal ACS Nano presents a novel immunotherapy approach to treating haematological...

Abstract:

Neutrophils play a critical role in the innate immune response but their dysregulated recruitment and activation can drive tissue damage in chronic inflammatory conditions. This review examines current understanding of the molecular mechanisms regulating...

Introduction

Regulatory T cells (Tregs) play a crucial role in maintaining immune homeostasis and preventing autoimmunity. However, in certain contexts, such as cancer immunotherapy, the suppressive function of Tregs can hinder effective immune responses against tumors. Targeting...