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ichorbio Citations (Resources)
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August 15, 2025
Humoral Immunity's Unexpected Role in Checkpoint Immunotherapy
A recent article published in Nature (Vol. 631, 23 July 2025) reveals that antibody-mediated humoral immunity, specifically the presence of autoantibodies (AAbs), can significantly influence the effectiveness of checkpoint immunotherapy (CPI) for cancer. The study, which used a high-throughput...
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July 28, 2025
Oncolytic Virus Expressing Non-Secreted DR-18 Cytokine Induces Potent, Systemic Antitumor Immunity
A recent study published in
Molecular Therapy: Oncology (Vol. 33, Sept 2025) demonstrates the therapeutic potential of a novel oncolytic vaccinia...
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June 24, 2025
Does Dietary Fiber Really Boost Immunotherapy? A Closer Look at Inconsistent Outcomes in Murine Tumor Models
Introduction
Dietary fiber has long been heralded as a health-promoting nutrient, with recent studies suggesting it may enhance the efficacy of immune checkpoint blockade (ICB) therapies by modulating the gut microbiome. However...
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May 02, 2025
Multiantigen T Cell Engagers (MATCH): A New Frontier in Treating Pediatric Leukemia
Introduction
Despite advances in immunotherapy, relapse remains a major hurdle in B-cell malignancies, particularly due to immune evasion through antigen loss. While CD19- and CD20-targeted immunotherapies have transformed treatment paradigms, they are prone...
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April 07, 2025
In a groundbreaking study, Fausther-Bovendo et al. have developed a novel, rapid, and cost-effective method for screening therapeutic monoclonal antibody (mAb) candidates and cocktails directly in living systems. This advancement holds significant promise for accelerating the fight against emerging and rapidly mutating pathogens, as well as for applications in cancer and autoimmune diseases.
Key Findings...
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December 17, 2024
eNAMPT Drives Abnormal Blood Vessel Formation in Triple-Negative Breast Cancer Through Direct Effects on Pericytes
A groundbreaking study published in Angiogenesis reveals a previously unknown mechanism by which extracellular nicotinamide phosphoribosyltransferase (eNAMPT) promotes tumor progression through direct effects on blood vessel formation. The research team...
