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ichorbio Citations (Resources)
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June 24, 2025
Does Dietary Fiber Really Boost Immunotherapy? A Closer Look at Inconsistent Outcomes in Murine Tumor Models
Introduction
Dietary fiber has long been heralded as a health-promoting nutrient, with recent studies suggesting it may enhance the efficacy of immune checkpoint blockade (ICB) therapies by modulating the gut microbiome. However...
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May 02, 2025
Multiantigen T Cell Engagers (MATCH): A New Frontier in Treating Pediatric Leukemia
Introduction
Despite advances in immunotherapy, relapse remains a major hurdle in B-cell malignancies, particularly due to immune evasion through antigen loss. While CD19- and CD20-targeted immunotherapies have transformed treatment paradigms, they are prone...
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April 07, 2025
In a groundbreaking study, Fausther-Bovendo et al. have developed a novel, rapid, and cost-effective method for screening therapeutic monoclonal antibody (mAb) candidates and cocktails directly in living systems. This advancement holds significant promise for accelerating the fight against emerging and rapidly mutating pathogens, as well as for applications in cancer and autoimmune diseases.
Key Findings...
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December 17, 2024
eNAMPT Drives Abnormal Blood Vessel Formation in Triple-Negative Breast Cancer Through Direct Effects on Pericytes
A groundbreaking study published in Angiogenesis reveals a previously unknown mechanism by which extracellular nicotinamide phosphoribosyltransferase (eNAMPT) promotes tumor progression through direct effects on blood vessel formation. The research team...
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December 17, 2024
Breakthrough in De Novo Antibody Design Achieves Therapeutic-Grade Properties
A transformative paper from Nabla Bio demonstrates a significant leap forward in computational antibody design, showing that de novo methods can now achieve therapeutic-grade properties without experimental optimization. Their system, called JAM (Joint Atomic Modeling), represents a major...
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November 05, 2024
Dual Role of cGAS/STING Signaling in Colorectal Cancer Chemotherapy: Friend or Foe?
Introduction
Colorectal cancer (CRC) remains a significant health challenge, with FOLFOX chemotherapy (combining 5-FU, oxaliplatin, and leucovorin) being a first-line treatment. While immunotherapies like...
