Atibuclimab Biosimilar - Research Grade

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$300.00 - $5,000.00

Atibuclimab Biosimilar - Research Grade manufactured in Oxford, United Kingdom. Bulk quantities of Atibuclimab biosimilar in stock in UK and USA.

SKU:
ICH5016
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Atibuclimab Biosimilar - Research Grade

Product Details:

ichorbio's atibuclimab biosimilar is for Research Use Only (RUO)

Size:

ichorbio's RUO atibuclimab biosimilar is available in the following sizes: 1mg, 5mg, 10mg, 20mg, 50mg, 100mg ichorbio regularly manufactures bulk multi-gram amounts of this biosimilar - please contact us for pricing.

Target:

CD14

Isotype:

IgG4

Other Names:

IC14

Host:

CHO cells

Species Reactivity:

Human

Specificity:

Detects human CD14.

Purification Method:

This recombinant protein was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background:

RUO atibuclimab is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis. It acts as a pattern recognition receptor for bacterial cell wall components in gram-positive and negative bacteria. CD14 antibody action stimulates a pro-inflammatory cytokine cascade often associated with inflammation in sepsis. Atibuclimab neutralization of this antibody results in the inhibition of TNF-a, IL-6 and IL-10, dampening systemic inflammatory responses. Atibuclimab also delays the release of sTNFR(1) and IL-1ra.

Concentration:

1.0 - 5.0 mg/ml

Formulation:

Sterile, preservative-free, solution in PBS. BSA and Azide free.

Purity:

>95% by SDS-PAGE and HPLC

Endotoxin:

≤ 1.0 EU/mg as determined by the LAL method

Storage:

Atibuclimab Biosimilar - Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Applications:

Functional Assays

Application Notes:

Each investigator should determine their own optimal working dilution for specific applications.

Isotype Control:

Bulk Human IgG4 Isotype Control (IB4) [ICH2257]

Use: ichorbio's atibuclimab biosimilar is for research use only (RUO).

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