Natalizumab Biosimilar - Research Grade

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SKU

ICH4037

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$306.00

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Bulk Natalizumab Biosimilar - Research Grade

Product Benefits:

ichorbio's Natalizumab Biosimilar - Research Grade is manufactured in a cGMP compliant facility.

Size:

ichorbio's research grade natalizumab biosimilar is available in the following sizes: 5mg, 10mg, 20mg, 50mg, 100mg ichorbio regularly manufactures bulk multi-gram amounts of our natalizumab biosimilar - research grade. Please contact us for pricing.

Target:

α4β1 integrin

Clone:

n/a

Isotype:

Human IgG4

Other Names:

alpha-4 integrin

Host:

CHO Cells

Species Reactivity:

Human

Specificity:

Detects human α4β1 integrin.

Purification Method:

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background:

Natalizumab biosimilar - research grade is a humanized monoclonal antibody that blocks α4β1 integrin. It is an IgG1 kappa immunoglobulin with an approximate molecular weight of 149 kDa.

Concentration:

1.0 - 5.0 mg/ml

Formulation:

Sterile, preservative-free, buffer includes sodium chloride; sodium phosphate, monobasic, monohydrate; sodium phosphate, dibasic, heptahydrate; polysorbate 80, pH 6.1. BSA and Azide free.

Purity:

>98% by SDS-PAGE and HPLC

Endotoxin:

≤ 1.0 EU/mg as determined by the LAL method

Storage:

Natalizumab is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Applications:

Functional Assays

Application Notes:

Each investigator should determine their own optimal working dilution for specific applications.

Isotype Control:

Bulk Human IgG4 Isotype Control (IB4) [ICH2257]

Use: ichorbio's natalizumab biosimilar is for research use only (RUO).

More Information
Concentration	9.73mg/ml
Isotype	Human IgG4
Host	CHO Cells
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Application Notes	This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.
Applications	Functional Assays
Storage	This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.
Endotoxin	<1EU/mg Determined by LAL gel clotting assay
Purity	≥95% monomer by analytical SEC, >95% by SDS Page
Formulation	Sterile, preservative-free, solution in PBS. BSA and Azide free.
Purification Method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Specificity	Detects human CD49d
Species Reactivity	Human
Target	CD49d
Shipping Conditions	Blue ice
background	Uses the same sequence as the therapeutic antibody natalizumab
Other names	ITGA4, CD49D, IA4, integrin subunit alpha 4
Buffer	ICH3001-100ml ICH3002-100ml ICH3003-100ml
Sequence	https://www.imgt.org/mAb-DB/