in vivo research

B-cells play a paradoxical role in preclinical disease models. In autoimmune diseases like Systemic Lupus Erythematosus (SLE) and Multiple Sclerosis (EAE), they are the primary pathogenic drivers. In immuno-oncology, their presence in the Tumor Microenvironment (TME) can...

1. Understanding CD8+ T Cell Depletion

The fall or removal of CD8+ T cells, a form of T cell depletion, leads to the recognition and eradicating of various abnormal cells, virally infected cells, and tumor cells because CD8+ T cells are essential components of the immune defense system [1]. There are several ways to eliminate T cells, but antibody-based depletion has become a breakthrough in the respective...

Introduction...

Abstract:

Effective...