Utomilumab Biosimilar – Research Grade
ichorbio’s utomilumab biosimilar is for Research Use Only (RUO) and not for therapeutic use.
ichorbio’s RUO utomilumab biosimilar is available in the following sizes:
0.1mg, 5mg, 10mg, 20mg, 50mg
ichorbio regularly manufactures bulk multi-gram amounts of this biosimilar – please contact us for pricing.
4-1BB ligand receptor, T-cell antigen 4-1BB, Tnfrsf9, Ila, Ly63, CD137
Detects human 4-1BB. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody utomilumab.
This recombinant protein was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
RUO Utomilumab is a fully-human IgG2 agonist mAb that selectively binds human 4-1BB/CD137, resulting in NF-κB activation and downstream cytokine production in cell lines and primary lymphocytes. Utomilumab can induce human leukocyte proliferation and has demonstrated significant antitumor activity as a single agent in human peripheral blood lymphocyte (PBL) SCID xenograft tumor models.
1.0 – 5.0 mg/ml
Sterile, preservative-free, solution in PBS. BSA and Azide free.
>95% by SDS-PAGE and HPLC
≤ 1.0 EU/mg as determined by the LAL method
Utomilumab Biosimilar – Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Each investigator should determine their own optimal working dilution for specific applications.
ichorbio’s utomilumab biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.