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Intratumoral Delivery of Interleukin 9 via Oncolytic Vaccinia Virus Elicits Potent Antitumor Effects in Tumor Models

by Junjie Ye, Lingjuan Chen, Julia Waltermire, Jinshun Zhao, Jinghua Ren, Zongsheng Guo, David L. Bartlett, and Zuqiang Liu

Cancers 2024, 16(5), 1021

https://doi.org/10.3390/cancers16051021 

Researchers from Allegheny...

Benguigui et al., 2024, Cancer Cell 42, 253–265
https://doi.org/10.1016/j.ccell.2023.12.005

Researchers from the Technion - Israel Institute of Technology and their collaborators have discovered a promising new biomarker for predicting patient response to cancer immunotherapy: interferon-stimulated neutrophils expressing high levels of the Ly6E protein (Ly6E(hi)...

Introduction

Immune...

This article is based on research found in the following publication:

Mine, K., Nagafuchi, S., Akazawa, S. et al. TYK2 signaling promotes the development of autoreactive CD8+ cytotoxic T lymphocytes and type 1 diabetes. Nat Commun15, 1337 (2024). https://doi.org/10.1038/s41467-024-45573-9

Type 1 diabetes (T1D) is an autoimmune disease where the body's...

Antibody therapeutics have made significant strides in recent years, with several successful treatments already in the market. However, the future of this field lies in the promising candidates currently in Phase I-II clinical trials. These antibodies, targeting a wide range of diseases, have the potential to become important treatments in the coming years.

One such antibody is DSP-0038, a humanized monoclonal antibody targeting the TROP2...

1. Target and Function

Belimumab is a human monoclonal antibody that targets and inhibits the biological activity of B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS) [1]. BAFF is a crucial survival factor for B cells and plays a significant role in the pathogenesis of systemic lupus erythematosus (SLE) [2].

2. Medical Uses

Belimumab is approved for the treatment of active, autoantibody-positive...

1. Target and Function

Tabalumab is a human monoclonal antibody that neutralizes both soluble and membrane-bound forms of B-cell activating factor (BAFF), a cytokine that promotes B-cell survival and differentiation [1]. By blocking BAFF, Tabalumab reduces B-cell numbers and activity, which may be beneficial in autoimmune diseases [2].

2. Medical Uses

Tabalumab has been investigated for the treatment of systemic...

1. Target and Function

Belantamab mafodotin is an antibody-drug conjugate (ADC) that targets B-cell maturation antigen (BCMA), a protein expressed on the surface of multiple myeloma cells [1]. The antibody is conjugated to monomethyl auristatin F (MMAF), a potent microtubule-disrupting agent, which induces cell death upon internalization [2].

2. Medical Uses

Belantamab is approved for the treatment of adult patients...

1. Target and Function

Aducanumab is a human monoclonal antibody that selectively targets amyloid-beta (Aβ) aggregates, a pathological hallmark of Alzheimer's disease (AD) [1]. By binding to Aβ, aducanumab promotes its clearance and reduces the formation of amyloid plaques in the brain [2].

2. Medical Uses

Aducanumab is approved by the U.S. Food and Drug Administration (FDA) for the treatment of AD, specifically for patients w...

Pursuing a PhD is a challenging and rewarding journey that requires dedication, perseverance, and strategic planning. While the path to a successful PhD is unique for each individual, there are several key principles that can help doctoral candidates navigate the process and achieve their goals. From developing a strong research plan to cultivating professional relationships, this guide offers insights into making your PhD a success.

One...