Rituximab Biosimilar – Research Grade: LALAPG
ichorbio’s Rituximab Biosimilar – Research Grade is manufactured in a cGMP compliant facility. This version of rituximab is Fc Silenced using the LALAPG mutation
ichorbio’s research grade rituximab biosimilar is available in the following sizes:
0.5mg, 1mg, 5mg, 10mg, 20mg
ichorbio regularly manufactures bulk multi-gram amounts of our Fc silenced rituximab biosimilar – please contact us for pricing.
CD20
n/a
Human IgG1-Kappa
B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, MS4A1
Humanized
Human
Detects human CD20. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Rituximab with a LALAPG mutation in the Fc region. ichorbio’s rituxumab biosimilar is for research use only (RUO).
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Rituximab is a genetically engineered chimeric murine/human monoclonal IgG1 kappa antibody directed against the CD20 antigen. Rituximab has an approximate molecular weight of 145 kD. ichorbio’s Rituximab is produced in mammalian cells -Chinese Hamster Ovary.
1.0 – 5.0 mg/ml
Sterile, clear, colorless, preservative-free solution containing polysorbate 80, sodium chloride, sodium citrate. The pH is 6.5. BSA and Azide free.
>95% by SDS-PAGE and HPLC
≤ 0.75 EU/mg as determined by the LAL method
Rituximab Biosimilar – Research Grade: LALAPG is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Functional Assays
Each investigator should determine their own optimal working dilution for specific applications.
ichorbio’s Fc silenced rituximab biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.
Bulk Human IgG1 Isotype Control (IB1) LALAPG [ICH2254LALAPG]
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