Odronextamab Biosimilar – Research Grade [ICH5027]

ichorbio’s odronextamab biosimilar is for Research Use Only (RUO) and not for therapeutic use.

ichorbio’s RUO odronextamab biosimilar is available in the following sizes:
0.1mg, 5mg, 10mg, 20mg, 50mg
ichorbio regularly manufactures bulk multi-gram amounts of this biosimilar – please contact us for pricing.

CD3/CD20

n/a

Bispecific

REGN 1979

CHO

Human

Detects human CD3/CD20. This non-therapeutic antibody uses the same sequence as odronextamab.

This recombinant protein was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

ichorbio’s Odronextamab biosimilar is a hinge-stabilized, fully human IgG4-based CD3 x CD20 bispecific antibody (bsAb) that has demonstrated encouraging safety, tolerability and preliminary efficacy in a first-in-human study of patients with relapsed/refractory B-cell non-Hodgkin lymphoma.

1.0 – 5.0 mg/ml

Sterile, preservative-free, solution in PBS. BSA and Azide free.

>95% by SDS-PAGE and HPLC

≤ 1.0 EU/mg as determined by the LAL method

Odronextamab biosimilar – Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Functional Assays

Each investigator should determine their own optimal working dilution for specific applications.