Odronextamab Biosimilar – Research Grade [ICH5027]

ichorbio’s Odronextamab Biosimilar – Research Grade is for Research Use Only (RUO) and not for therapeutic use.

CD3/CD20

ichorbio’s biosimilars are available in the following sizes:
1mg, 5mg, 10mg, 20mg, 50mg, 100mg

Human IgG4

REGN 1979

CHO cells

Human

Detects human CD3/CD20. This non-therapeutic antibody uses the same sequence as the therapeutic antibody odronextamab.

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

ichorbio’s Odronextamab biosimilar is a hinge-stabilized, fully human IgG4-based CD3 x CD20 bispecific antibody (bsAb). The drug has demonstrated encouraging safety, tolerability and preliminary efficacy in a first-in-human study of patients with relapsed/refractory B-cell non-Hodgkin lymphoma.

5mg/ml

Sterile, preservative-free, solution in PBS. BSA and Azide free.

>95% by SDS-PAGE

≤ 1.0 EU/mg as determined by the LAL method

This antibody is stable for at least 4 weeks when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at – 20°C or -80°C. Avoid repeated freeze thaw cycles.

Functional Assays

This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.

Bulk Human IgG4 Isotype Control (IB4) [ICH2257]