Monalizumab Biosimilar – Research Grade [ICH5017]

ichorbio’s monalizumab biosimilar is for Research Use Only (RUO) and not for therapeutic use.

ichorbio’s RUO monalizumab biosimilar is available in the following sizes:
1mg, 5mg, 10mg, 20mg, 50mg, 100mg
ichorbio regularly manufactures bulk multi-gram amounts of this biosimilar – please contact us for pricing.

NKG2A

IgG4

KLRC1, CD159a, CD94

CHO cells

Human

Detects human NKG2A. This non-therapeutic antibody uses the same sequence as the therapeutic antibody monalizumab.

This recombinant protein was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

RUO monalizumab is a blocking antibody that prevents the inhibition of CD8+ T cells and NK cell by tumor cells expressing HLA-E. By acting simultaneously on innate and adaptive immunity, monalizumab may re-establish a broad anti-tumor response.

1.0 – 5.0 mg/ml

Sterile, preservative-free, solution in PBS. BSA and Azide free.

>95% by SDS-PAGE and HPLC

≤ 1.0 EU/mg as determined by the LAL method

Monalizumab Biosimilar – Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Functional Assays

Each investigator should determine their own optimal working dilution for specific applications.

Bulk Human IgG4 Isotype Control (IB4) [ICH2257]