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M7824 Biosimilar – Research Grade [ICH5006]

$718.00 – $4,161.00

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M7824 Biosimilar – Research Grade [ICH5006]
SKU: ICH5006 Categories: anti-human, Biosimilar Antibodies, Low Endotoxin
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M7824 Biosimilar – Research Grade

Product Benefits:

ichorbio’s M7824 Biosimilar is for Research Use Only (RUO) and not for therapeutic use.

Size:

ichorbio’s RUO M7824 biosimilar is available in the following sizes:
5mg, 10mg, 20mg, 50mg
ichorbio regularly manufactures bulk multi-gram amounts of this biosimilar – please contact us for pricing.

Target:

PD-L1 & TGF-B

Clone:

n/a

Isotype:

IgG1 kappa

Other Names:

Programmed cell death 1 ligand 1, Cd274, PDCD1 ligand 1, Programmed death ligand 1, B7 homolog 1, B7-H1, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1, PDL-1

Host:

CHO

Species Reactivity:

Human

Specificity:

Detects human PD-L1 & TGF-beta. This non-therapeutic antibody uses the same variable region sequence as the therapeutic fusion protein M7824.

Purification Method:

This recombinant protein was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background:

RUO M7824 is a bi-functional fusion protein composed of a human IgG1 monoclonal antibody against PD-L1 fused with 2 extracellular domains of TGF-βRII (a TGF-β “trap”). It is an IgG1 kappa immunoglobulin with an approximate molecular weight of 149 kDa.

Concentration:

1.0 – 5.0 mg/ml

Formulation:

Sterile, preservative-free, solution in PBS. BSA and Azide free.

Purity:

>95% by SDS-PAGE and HPLC

Endotoxin:

≤ 1.0 EU/mg as determined by the LAL method

Storage:

M7824 Biosimilar – Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Applications:

Functional Assays

Application Notes:

Each investigator should determine their own optimal working dilution for specific applications.

Use:

ichorbio’s M7824 biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.

Size:

0.1mg, 5mg, 10mg, 20mg, 50mg

Endotoxin Level:

Low

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