M7824 Biosimilar – Research Grade [ICH5006]

ichorbio’s M7824 Biosimilar is for Research Use Only (RUO) and not for therapeutic use.

ichorbio’s RUO M7824 biosimilar is available in the following sizes:
5mg, 10mg, 20mg, 50mg
ichorbio regularly manufactures bulk multi-gram amounts of this biosimilar – please contact us for pricing.

PD-L1 & TGF-B

n/a

IgG1 kappa

Programmed cell death 1 ligand 1, Cd274, PDCD1 ligand 1, Programmed death ligand 1, B7 homolog 1, B7-H1, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1, PDL-1

CHO

Human

Detects human PD-L1 & TGF-beta. This non-therapeutic antibody uses the same variable region sequence as the therapeutic fusion protein M7824.

This recombinant protein was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

RUO M7824 is a bi-functional fusion protein composed of a human IgG1 monoclonal antibody against PD-L1 fused with 2 extracellular domains of TGF-βRII (a TGF-β “trap”). It is an IgG1 kappa immunoglobulin with an approximate molecular weight of 149 kDa.

1.0 – 5.0 mg/ml

Sterile, preservative-free, solution in PBS. BSA and Azide free.

>95% by SDS-PAGE and HPLC

≤ 1.0 EU/mg as determined by the LAL method

M7824 Biosimilar – Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Functional Assays

Each investigator should determine their own optimal working dilution for specific applications.