Bulk Denosumab Biosimilar – Research Grade
ichorbio’s Denosumab Biosimilar – Research Grade is manufactured in a cGMP compliant facility.
ichorbio’s research grade denosumab biosimilar is available in the following sizes:
5mg, 10mg, 20mg, 50mg, 100mg
ichorbio regularly manufactures bulk multi-gram amounts of our denosumab biosimilar – please contact us for pricing.
RANKL
n/a
IgG2
Tumor necrosis factor ligand superfamily member 11, Tnfsf11, Osteoclast differentiation factor, ODF, Osteoprotegerin ligand, OPGL, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, TRANCE, CD254, Rank Ligand
Humanized
Human
Detects human RANK Ligand. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Denosumab. This denosumab biosimilar is for research use only (RUO).
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Denosumab biosimilar is a human IgG2 monoclonal antibody that binds to human RANKL. Denosumab has an approximate molecular weight of 147 kDa and is produced in genetically engineered mammalian (Chinese hamster ovary) cells.
1.0 – 5.0 mg/ml
Sterile, clear, colorless to pale yellow, preservative-free solution, containing acetic acid, poly Sorbate 20 and sorbitol, pH 5.2. BSA and Azide free.
>95% by SDS-PAGE and HPLC
≤ 0.75 EU/mg as determined by the LAL method
Denosumab Biosimilar – Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Functional Assays
Each investigator should determine their own optimal working dilution for specific applications.
ichorbio’s denosumab biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.
james –
We did a comparison of the ichorbio denosumab biosimilar with Xgeva and are very pleased with the results. We will order in bulk soon.