Denosumab Biosimilar – Research Grade [ICH4019]

ichorbio’s Denosumab Biosimilar – Research Grade is manufactured in a cGMP compliant facility. ichorbio: the best antibodies for in vivo research.

ichorbio’s research grade denosumab biosimilar is available in the following sizes:
5mg, 10mg, 20mg, 50mg
ichorbio regularly manufactures bulk multi-gram amounts of our denosumab biosimilar – please contact us for pricing.

RANKL

n/a

IgG2

Tumor necrosis factor ligand superfamily member 11, Tnfsf11, Osteoclast differentiation factor, ODF, Osteoprotegerin ligand, OPGL, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, TRANCE, CD254, Rank Ligand

Humanized

Human

Detects human RANK Ligand. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Denosumab. This product is for research use only.

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Denosumab biosimilar is a human IgG2 monoclonal antibody that binds to human RANKL. Denosumab has an approximate molecular weight of 147 kDa and is produced in genetically engineered mammalian (Chinese hamster ovary) cells.

1.0 – 5.0 mg/ml

Sterile, clear, colorless to pale yellow, preservative-free solution, containing acetic acid, poly Sorbate 20 and sorbitol, pH 5.2. BSA and Azide free.

>95% by SDS-PAGE and HPLC

≤ 0.75 EU/mg as determined by the LAL method

Denosumab Biosimilar – Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Functional Assays

Each investigator should determine their own optimal working dilution for specific applications.