Anti-TCR Beta Antibody (H57-597)
ichorbio’s Anti-TCR Beta Antibody (H57-597) can be used for in vivo use as it has low endotoxin, no BSA or preservatives.
ichorbio’s Anti-Mouse TCR Beta In Vivo Antibody – Low Endotoxin (H57-597) is available in the following sizes:
5mg, 10mg, 20mg, 50mg
Armenian Hamster IgG
TCR-β chain, TCR-β, β-TCR
Clone H57-597 recognizes an epitope on the constant region of mouse TCRβ. Clone H57-597 does not cross-react with γδ T cells.
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
TCRβ is expressed on αβ thymocytes, peripheral T cells, and NKT cells.
TCRβ antibody, clone H57-597, recognizes the beta chain of the T cell receptor (TCRβ), expressed on αβ thymocytes and T lymphocytes, as well as natural killer T (NKT) cells. TCRβ is a transmembrane protein that consists of an amino-terminal variable region, a constant region, and a stalk segment covalently linked to the TCR alpha chain (TCRα) via a disulfide bond. TCRα/β does not contain signaling domains and is instead noncovalently associated with the CD3 complex (TCR-CD3), essential for TCR signaling. TCRα/β recognizes antigens bound to major histocompatibility complex (MHC) molecules, resulting in phosphorylation of CD3 ITAMs and subsequent T cell activation, proliferation, and survival.
Affinity purified TCR from mouse DO-11.10 cells
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 – 7.4 with no carrier protein, potassium, calcium or preservatives added.
≥95% monomer by analytical SEC, >95% by SDS Page
≤ 1.0 EU/mg as determined by the LAL method
This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Flow Cytometry, Costimulatory, Depletion, Immunoprecipitation, IHC (Frozen), IHC (Paraffin), CODEX.
The suggested concentration for this TCR β chain (clone H57-597) antibody for staining cells in flow cytometry is ≤ 0.25 μg per 10^6 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application.
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