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Bulk anti-Human CD119 antibody (GIR 208) [ICH1028]

$326.00 – $2,425.00

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Bulk anti-Human CD119 antibody (GIR 208) [ICH1028]
SKU: ICH1028 Categories: anti-human, ELISA, Flow Cytometry, Immunoprecipitation, Low Endotoxin, Neutralization, Ultra Low Endotoxin, Western Blot
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Bulk anti-human CD119 antibody (GIR 208)

 

Product Benefits:

ichorbio’s bulk anti-human CD119 antibody (GIR 208) is manufactured in a cGMP compliant facility. ichorbio’s low endotoxin antibodies have half the endotoxin of comparable antibodies from our competitors at less than 1.0 EU/mg. If ichorbio’s low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin (<0.75EU/mg) at an even higher purity (98% versus 95%). ichorbio: the best antibodies for in vivo research.

Target:

CD119

Clone:

GIR 208

Isotype:

Mouse IgG1

Other Names:

Interferon gamma receptor 1, IFN-gamma receptor 1, IFN-gamma-R1, CDw119, Interferon gamma receptor alpha-chain2, IFN-gamma-R-alpha

Uniprot:

P15260

Host:

Mouse

Species Reactivity:

Human

Specificity:

Bulk anti-human CD119 antibody (GIR 208) recognizes Human IFN gamma R alpha

Purification Method:

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Antigen Distribution:

The IFN-gamma receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes.

Background:

Interferon-gamma (IFN-gamma) exerts its biologic effects by interacting with a single high affinity receptor, IFN-gamma receptor. This receptor is present on almost all cell types except mature erythrocytes. The IFN-gamma receptor consists of two polypeptide chains alpha and beta and requires association of JAK1, JAK2 and Stat1 for IFN-gamma signal transduction. In signal transduction, IFN-gamma induces tyrosine phosphorylation of IFN-gamma receptor alpha (IFNGR1) leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-gamma induced gene transcription. The IFN-gamma receptor is structurally related to the recently cloned IL-10 receptor. GIR 208 binds IFNGR1 and blocks binding of IFN-gamma to the receptor.

Immunogen:

Human IFN-gamma R alpha, Purified from human placenta

Concentration:

1.0 – 5.0 mg/ml

Formulation:

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.

Purity:

>95% by SDS-PAGE and HPLC

>98% by SDS-PAGE and HPLC

Endotoxin:

≤ 1.0 EU/mg as determined by the LAL method

≤ 0.75 EU/mg as determined by the LAL method

Aggregation:

Aggregation level ≤ 5%

Aggregation level ≤ 1%

IMPACT Pathogen Test:

We use the IMPACT test generated by IDEXX Laboratories to guarantee our Ultra Low Endotoxin antibodies are pathogen free. Our mouse antibodies are tested for:
Mycoplasma spp.
Mycoplasma pulmonis
Sendai virus
Mouse hepatitis virus
Pneumonia virus of mice
Minute virus of mice
Mouse parvovirus (MPV1-5)
Theiler’s murine encephalomyelitis virus
Murine norovirus
Reovirus 3
Mouse rotavirus
Ectromelia virus
Lymphocytic choriomeningitis virus
Polyoma virus
Lactate dehydrogenase-elevating virus
Mouse adenovirus (MAD1, MAD2)
Mouse cytomegalovirus
K virus
Mouse thymic virus
Hantaan virus
Corynebacterium bovis
Corynebacterium spp. (HAC2)

Storage:

Anti-human CD119 antibody (GIR 208) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Applications:

Immunoprecipitation, Western Blot, ELISA, Neutralization, Flow Cytometry

Application Notes:

Each investigator should determine their own optimal working dilution for specific applications.

Use:

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Isotype Control:

Mouse IgG1 Isotype Control for In Vivo – Low Endotoxin [HKSP] (ICH2247)

Related Antibody:

Anti-CD119 In Vivo Antibody – Ultra Low Endotoxin [GIR 208] (ICH1028UL)

Size:

1mg, 5mg, 25mg, 50mg, 100mg

Endotoxin Level:

Low, Ultra Low

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