Bulk Alirocumab Biosimilar – Research Grade
ichorbio’s Alirocumab Biosimilar – Research Grade is manufactured in a cGMP compliant facility. ichorbio: the best antibodies for in vivo research.
ichorbio’s research grade alirocumab biosimilar is available in the following sizes:
5mg, 10mg, 20mg, 50mg
ichorbio regularly manufactures bulk multi-gram amounts of our alirocumab biosimilar – please contact us for pricing.
Proprotein convertase subtilisin/kexin type 9, NARC-1, PC9
Detects human PCSK9. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Alirocumab.
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Alirocumab biosimilar is a human monoclonal antibody (IgG1 isotype) that targets proprotein convertase subtilisin kexin type 9 (PCSK9), is a PCSK9 inhibitor produced by recombinant DNA technology in Chinese Hamster Ovary cell suspension culture. Alirocumab biosimilar consists of two disulfide-linked human heavy chains, each covalently linked through a disulfide bond to a human kappa light chain. A single Nlinked glycosylation site is located in each heavy chain within the CH2 domain of the Fc constant region of the molecule. The variable domains of the heavy and light chains combine to form the PCSK9 binding site within the antibody. Alirocumab biosimilar has an approximate molecular weight of 146 kDa.
1.0 – 5.0 mg/ml
Sterile, clear, colorless to pale yellow, preservative-free liquid, which contains histidine, polysorbate, sucrose, pH 6.0. BSA and Azide free.
>95% by SDS-PAGE and HPLC
≤ 0.75 EU/mg as determined by the LAL method
Alirocumab Biosimilar – Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Each investigator should determine their own optimal working dilution for specific applications.
ichorbio’s alirocumab biosimilar is for research use only: it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.