Bulk Aflibercept Biosimilar – Research Grade
ichorbio’s Aflibercept Biosimilar – Research Grade is manufactured in a cGMP compliant facility. Our aflibercept biosimilar is for research use only (RUO).
ichorbio’s research grade aflibercept biosimilar is available in the following sizes: 1mg, 5mg and 20mg. ichorbio regularly manufactures bulk multi-gram amounts of our aflibercept biosimilar – please contact us for pricing.
Vascular Endothelial Growth Factor
Detects human VEGF. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Aflibercept.
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Aflibercept biosimilar is a recombinant fusion protein consisting of portions of human VEGF receptors 1 and 2 extracellular domains fused to the Fc portion of human IgG1 formulated as an iso-osmotic solution for intravitreal administration. Aflibercept biosimilar is a dimeric glycoprotein with a protein molecular weight of 97 kilodaltons (kDa) and contains glycosylation, constituting an additional 15% of the total molecular mass, resulting in a total molecular weight of 115 kDa. Aflibercept biosimilar is produced in recombinant Chinese hamster ovary (CHO) cells.
1.0 – 5.0 mg/ml
Preservative-free, sterile, aqueous solution. 40 mg/mL aflibercept in 10 mM sodium phosphate, 40 mM sodium chloride, 0.03% polysorbate 20, and 5% sucrose, pH 6.2. BSA and Azide free.
>95% by SDS-PAGE and HPLC
≤ 0.75 EU/mg as determined by the LAL method
Aflibercept Biosimilar – Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Each investigator should determine their own optimal working dilution for specific applications.