Ado-trastuzumab emtansine Biosimilar – Research Grade [ICH4014]

ichorbio’s Ado-trastuzumab emtansine Biosimilar – Research Grade is manufactured in a cGMP compliant facility. Our ado-trastuzumab emtansine biosimilar is for research use only (RUO).

ichorbio’s research grade ado-trastuzumab emantsine biosimilar is available in the following sizes:
5mg, 20mg, 100mg
ichorbio regularly manufactures bulk multi-gram amounts of our ado-trastuzumab emantsine biosimilar – please contact us for pricing.

ErbB2

n/a

IgG1

Receptor tyrosine-protein kinase erbB-2, MLN 19, HER2, HER2/neu

Humanized

Human

Detects human HER2. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Ado-trastuzumab emtansine.

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Ado-trastuzumab emtansine is a HER2-targeted antibody-drug conjugate which contains the humanized anti-HER2 IgG1, trastuzumab, covalently linked to the microtubule inhibitory drug DM1 via the stable thioether linker MCC. Trastuzumab is produced by Chinese hamster ovary cells, and DM1-MCC are produced by chemical synthesis. Ado-trastuzumab emtansine contains an average of 3.5 DM1 molecules per antibody.

1.0 – 5.0 mg/ml

Sterile, colorless liquid without preservatives, containing polysorbate 20, sodium succinate, sucrose, pH 5.0. BSA and Azide free.

>95% by SDS-PAGE and HPLC

≤ 0.75 EU/mg as determined by the LAL method

This antibody is stable for at least 4 weeks when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at – 20°C or -80°C. Avoid repeated freeze thaw cycles.

Functional Assays

Each investigator should determine their own optimal working dilution for specific applications.