CD40 Antibodies for in vivo use

ichorbio manufactures clones FGK4.5 & G28.5, two anti-CD40 antibodies for in vivo use. FGK4.5 is an anti-mouse antibody, G28.5 is an anti-human antibody.

ichorbio manufactures FGK4.5 in bulk quantities – 5mg to 100mg as standard with 1g lots manufactured each time. Stock of clone FGK4.5 is held in both the UK and USA. FGK4.5 is sometimes referred to as FGK45 by other manufacturers and in citations. They are the same clone.

Low Endotoxin Antibodies to CD40

Biosimilar antibodies to CD40

ichorbio also supplies three biosimilars that target CD40, selicrelumab, sotigalimab and dacetuzumab. These biosimilars are all provided in low endotoxin format so can also be used in vivo.

CD40 Background

CD40 functions as a receptor for TNFSF5/CD40LG. CD40 transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.

CD40 is an immune checkpoint molecule.