CD28 antibodies for in vivo use

ichorbio supplies a small range of products related to CD28; both low endotoxin antibodies which are suitable for in vivo use. ICH1055 is an anti-mouse CD28 antibody – clone 37.51. ICH1013 is an anti-human CD28 antibody, clone CD28.2.

Low Endotoxin Antibodies to CD28

Biosimilar Antibodies to CD28

ichorbio has developed a single biosimilar that targets CD28, Theralizumab. This antibody is low endotoxin and can also be used in vivo:

CD28 Background

CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular).

CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins. When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen-presenting cells (APCs). The CD86 expression on antigen-presenting cells is constitutive (expression is independent of environmental factors).

CD28 is the only B7 receptor constitutively expressed on naive T cells. Association of the TCR of a naive T cell with MHC:antigen complex without CD28:B7 interaction results in a T cell that is anergic.